Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2019.269

A CANDIDATE GENE ASSOCIATION STUDY OF FKBP5 AND CRHR1 POLYMORPHISMS IN RELATION TO WAR-RELATED POSTTRAUMATIC STRESS DISORDER

Nenad Jaksic ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Emina Šabić Džananović ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Branka Aukst Margetic ; Department of Psychiatry, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Dusko Rudan ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Ana Cima Franc ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Nada Bozina ; School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia
Elma Ferić Bojić ; Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina
Sabina Kučukalić ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Alma Džubur Kulenović ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Damir Marjanović ; Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina
Esmina Avdibegović ; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina
Dragan Babić ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Ferid Agani ; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo
Abdulah Kučukalić ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Alma Bravo Mehmedbašić ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Nermina Kravic ; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina
Mirnesa Muminović Umihanić ; Community Health Center Zivinice, Zivinice, Bosnia and Herzegovina
Osman Sinanović ; Department of Neurology, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina
Romana Babić ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Marko Pavlović ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Shpend Haxhibeqiri ; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Aferdita Goci Uka ; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Blerina Hoxha ; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Valdete Haxhibeqiri ; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Christiane Ziegler ; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
Christiane Wolf ; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany
Bodo Warrings ; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany
Katharina Domschke ; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
Jürgen Deckert ; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany
Miro Jakovljevic ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia;School of Medicine, University of Zagreb, Zagreb, Croatia

Sažetak

Background: Posttraumatic stress disorder (PTSD) is a highly frequent and disabling psychiatric condition among war-affected populations. TheFK506-binding protein 5 (FKBP5) gene and the corticotropin releasing hormone receptor 1 (CRHR1) gene have previously been implicated in an elevated risk of peritraumatic dissociation and PTSD development. Our aim was to investigate the association between FKBP5 and CRHR1 genotypes and PTSD diagnosis and severity among individuals who were affected by the Balkan wars during the 1990s.
Subjects and methods: This study included participants with current PTSD, remitted PTSD and healthy volunteers (N=719, 487 males), who were recruited between 2013 and 2015 within the framework of the South Eastern Europe (SEE) - PTSD Study. Psychometric methods comprised the Mini International Neuropsychiatric Interview (M.I.N.I.), the Clinician Administrated PTSD Scale (CAPS), and the Brief Symptom Inventory (BSI). FKBP5 rs1360780 and CRHR1 rs17689918 genotypes were determined using a KASP genotyping assay.
Results: Tests for deviation from Hardy Weinberg equilibrium showed no significant results. Logistic and linear regression was used to examine the associations between the FKBP5 SNP rs1360780 and the CRHR1 SNP rs17689918 with PTSD diagnosis and severity, as well as general psychiatric symptom severity, separately for current and remitted PTSD patients. There were nominally significant associations under a dominant model between the rs1360780 C allele and PTSD diagnosis as well as symptom severity, which however, were not significant anymore after Bonferroni adjustment (????=0.002). For CRHR1 rs17689918 no significant associations were detected.
Conclusion: We found nominally, but not Bonferroni corrected significant associations between the FKBP5 polymorphism rs1360780 and PTSD susceptibility among individuals affected by the Balkan wars. For elucidating this gene’s real resilience/ vulnerability potential, environmental influences should be taken into account.

Ključne riječi

PTSD; FKBP5; CRHR1; trauma; war

Hrčak ID:

235185

URI

https://hrcak.srce.hr/235185

Datum izdavanja:

9.7.2019.

Posjeta: 1.027 *