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Veterinarski arhiv, Vol. 90 No. 1, 2020.

Izvorni znanstveni članak

https://doi.org/10.24099/vet.arhiv.0342

The effect of piperine pre-conditioning on the pharmacokinetics of orally administered marbofloxacin in rats

Vipul B. Chauhan ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh, India
Chirag M. Modi orcid id orcid.org/0000-0002-2895-4469 ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh, India
Urvesh D. Patel ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh, India
Harshad B. Patel ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh, India

Puni tekst: engleski pdf 606 Kb

str. 69-75

preuzimanja: 547

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Sažetak

The present study was carried out to evaluate the effect of piperine pre-conditioning on the pharmacokinetics of marbofloxacin in Wistar rats. Marbofloxacin was administrated at a dose rate of 5 mg/kg body weight alone, and along with piperine pre-conditioning at a dose of 10 mg/kg of body weight, orally for 5 days in Wistar rats. The mean values of the half-life (t1⁄2β), maximum drug concentration (Cmax) and area under the curve (AUC) were 1.19 ± 0.17 h, 2.71 ± 0.09 μg/mL and 12.25 ± 0.77 μg.h/mL, respectively, in piperine pretreated rats. The values were significantly higher than the values observed in rats administered with marbofloxacin alone (1.12 ± 0.31 h, 2.28 ± 0.20 μg/mL and 9.24 ± 0.59 μg.h/mL, respectively). The drug clearance (ClB) in piperine pretreated rats was 0.04 ± 0.02 L/h/kg, which was significantly lower than the clearance rate of the drug (0.53 ± 0.03 L/h/kg) in the animals administered with marbofloxacin alone. The study reveals that piperine has a significant effect on the pharmacokinetics of marbofloxacin, which may be due to an increase in the drug absorption and inhibition of elimination of the drug in rats.

Ključne riječi

piperine pre-conditioning; pharmacokinetics; marbofloxacin; Wistar rats

Hrčak ID:

235741

URI

https://hrcak.srce.hr/235741

Datum izdavanja:

16.3.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.555 *