Skoči na glavni sadržaj

Psychiatria Danubina, Vol. 32 No. 1, 2020.

Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2020.92

POTENTIAL PROTECTIVE ROLE OF SDF-1 AND CXCR4 GENE VARIANTS IN THE DEVELOPMENT OF DEMENTIA

Burak Dalan ; Yeditepe University, Istanbul, Turkey
Ozlem Timirci-Kahraman ; Istanbul University, Aziz Sancar DETAE, Istanbul, Turkey
Seda Gulec-Yilmaz ; Yeditepe University, Institute of Health Science, Istanbul Turkey
Emre Murat Altinkilic ; Yeditepe University, Institute of Health Science, Istanbul Turkey
Selvi Duman ; Yeditepe University, Institute of Health Science, Istanbul Turkey
Huseyin Ayhan ; Yeditepe University, Institute of Health Science, Istanbul Turkey
Turgay Isbir ; Yeditepe University, Istanbul, Turkey

Puni tekst: engleski pdf 110 Kb

str. 92-96

preuzimanja: 357

citiraj

Sažetak

Background: The aim of this study was to evaluate the role of polymorphisms of stromal cell-derived factor-1 (SDF-1) and chemokine receptor-4 (CXCR4) genes in dementia susceptibility in a Turkish population.
Subjects and methods: The study group included 61 dementia patients, while the control group comprised 82 healthy individuals. Gene polymorphisms of SDF-1 3’A G801A (rs1801157) and CXCR4 C138T (rs2228014) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
Results: A significantly reduced risk for developing dementia was found for the group bearing an A allele for SDF-1 3’A polymorphism (p=0.009; x2=6.812; OR=0.626; 95%CI= 0.429-0.913). The frequency of the CXCR4 TT and TC genotype was significantly lower in patients with dementia compared to controls (p=0.028; x2=5.583; OR=0.215; 95%CI=0.05-0.914); (p=0.027; x2=4.919; OR=0.484; 95% CI= 0.246-0.955). Additionally, combined genotype analysis showed that the frequency of SDF1 GACXCR4 CC was significantly lower in patients with dementia in comparison with those of controls (p=0.049; OR=0.560; 95% CI= 0.307±1.020).
Conclusions: Our study provides new evidence that SDF1 A and CXCR4 T alleles may be associated with a decreased dementia risk. The present study is important because to our knowledge, it is the first one to be conducted in a Turkish population to date, but we believe that more patients and controls are needed to obtain statistically significant results.

Ključne riječi

SDF-1; CXCR4; dementia

Hrčak ID:

237063

URI

https://hrcak.srce.hr/237063

Datum izdavanja:

16.4.2020.

Posjeta: 755 *