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Pregledni rad

https://doi.org/10.21860/medflum2020_237297

Gout, contemporary insight into an ancient disease

Nadica Laktašić Žerjavić orcid id orcid.org/0000-0003-1279-3928 ; Medicinski fakultet, Sveučilište u Zagrebu, Klinika za reumatske bolesti i rehabilitaciju, Klinički bolnički centar Zagreb, Kišpatićeva 12, 10000 Zagreb, Hrvatska
Nadia Hoteit ; Medicinski fakultet, Sveučilište u Zagrebu, Šalata 3, 10000 Zagreb, Hrvatska
Dragica Soldo Jureša ; Medicinski fakultet, Sveučilište u Zagrebu, Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac, Klinička bolnica Merkur, Dugi dol 4a, 10000 Zagreb, Hrvatska


Puni tekst: hrvatski pdf 2.751 Kb

str. 97-112

preuzimanja: 5.752

citiraj


Sažetak

Gout is a chronic metabolic but at the same time inflammatory rheumatic disease which develops as a cosequence of increased urate concentration and deposites of monosodium urate crystals. The main cause of hyperuricaemia is renal urate underexcretion. In the pathogenesis of the inflammatory response to urate crystals, the phagocytosis of crystals by the macrophages is important, leading to activation of the NLRP3 inflammasome and the consequent release of the major proinflammatory cytokine interleukin 1β. Inadequate long-term treatment of hyperuricaemia leads to the development of chronic gout, which causes significant structural joint damage, disability and reduced quality of life. Therefore, long term urate lowering treatment aimed at maintaining urate concentrations < 350 umol/L in early disease and < 300 umol/L in chronic tophaceous disease is mandatory. Acute arthritis in gout, or a flaire in chronic arthritis should be treated with anti-inflammatory drugs: non-steroidal anti-inflammatory drugs, colchicine or glucocorticoids, mainly as a monotherapy. Patients with gout should be closely monitored for associated comorbidities, especially renal disease, hypertension, metabolic syndrome, and elevated cardiovascular risk.

Ključne riječi

comorbidity; crystal arthropathies; gout; hyperuricaemia

Hrčak ID:

237297

URI

https://hrcak.srce.hr/237297

Datum izdavanja:

1.6.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 7.507 *