Veterinarski arhiv, Vol. 76 No. 6, 2006.
Izvorni znanstveni članak
Gatifloxacin pharmacokinetics in buffalo calves after single intramuscular administration
Mukesh Raipuria
; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University,Ludhiana, India
Vinod Kumar Dumka
; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University,Ludhiana, India
Harpal Singh Sandhu
; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University,Ludhiana, India
Data Ram
; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University,Ludhiana, India
Sažetak
The pharmacokinetics and in vivo plasma protein binding of gatifloxacin after a single intramuscular injection of 4 mg/kg were studied in buffalo calves. The minimum therapeutic concentration of drug was maintained in plasma from 1 min to 12 h. Gatifloxacin was rapidly absorbed from the extravascular site of injection, as evident from the high value of absorption rate constant (4.91 ± 0.22 /h) and attained a Cmax of 2.98 ± 0.08 μg/mL at 1h. The area under the plasma concentration-time curve and apparent volume of distribution were 10.8 ± 0.64 μg/mL/h and 3.2 ± 0.08 L/kg, respectively. Elimination half-life and total body clearance were 7.45 ± 0.55 h and 301.5 ± 34.4 mL/kg/h, respectively. Cmax/MIC ratio was 14.9 ± 0.3 and systemic bioavailability was 79.7 ± 3.35 per cent. Gatifloxacin was bound to plasma proteins of buffalo calves to the extent of 25.0 ± 1.05 per cent. A suitable intramuscular dosage regimen of gatifloxacin in buffalo calves would be 6.0 mg/kg followed by 5.3 mg/kg at 24 h intervals.
Ključne riječi
buffalo calves; dosage; gatifloxacin; pharmacokinetics
Hrčak ID:
21945
URI
Datum izdavanja:
20.12.2006.
Posjeta: 1.504 *