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https://doi.org/10.11613/BM.2020.020706

Survey on request form content and result reporting in therapeutic drug monitoring service among laboratories in Czechia and Slovakia

Tomáš Šálek orcid id orcid.org/0000-0002-8392-5003 ; Department of Clinical Biochemistry and Pharmacology, Tomas Bata Hospital, Zlín, Czech Republic
Petr Schneiderka ; SEKK, spol. s.r.o., Pardubice, Czech Republic
Barbora Studená ; Institute of Clinical Biochemistry and Diagnostics, Medical Faculty in Hradec Králové, Charles University, Prague, Czech Republic
Michaela Votroubková ; Institute of Environmental and Chemical Engineering, University of Pardubice, Czech Republic


Puni tekst: engleski pdf 83 Kb

str. 272-277

preuzimanja: 175

citiraj


Sažetak

Introduction: The aim of the study was to investigate current practice and policies of therapeutic drug monitoring (TDM) service requesting and
result reporting in Czechia and Slovakia.
Materials and methods: All 149 laboratories that measure plasma drug concentrations were given an online questionnaire during a regular external
quality assessment TDM cycle. The questionnaire consisted of 17 questions. The optimal TDM practice was defined as the application of all elements
(age, body weight, time of sampling, date of the first administration, time of the last dose administration, the dose, the dosing interval, the
route of administration, information on reason of testing, and information on other co–administered drugs) needed for reporting a recommendation
for further drug dosing (positive response to question number 16).
Results: The response rate was 69%, 103 out of 149 laboratories measuring drug concentrations. Only 12% (12 out of 103 laboratories) of the laboratories
implemented all elements needed for optimal TDM practice and reported a recommendation. Both paper and electronic request forms
were used by 77 out of 103 (75%) laboratories. A total of 69 out of 103 laboratories (67%) specified the type of sampling tube on their request form.
Cystatin C was used for prediction of renal drug elimination by 24% (25 out of 103) of participants.
Conclusions: Small number of laboratories implemented all elements needed for optimal TDM practice and report a recommendation on further
dosing. Further efforts in education on optimal TDM practice as well as harmonization of service are desirable.

Ključne riječi

drug monitoring; pharmacokinetics; preanalytical phase; clinical laboratory services; kidney function tests

Hrčak ID:

238909

URI

https://hrcak.srce.hr/238909

Datum izdavanja:

15.6.2020.

Posjeta: 565 *