Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2018.59.290
Impact of pharmacotherapeutic education on medication adherence and adverse outcomes in patients with type 2 diabetes mellitus: a prospective, randomized study
Srećko Marušić
orcid.org/0000-0002-3982-0765
; Medical Department, University Hospital Dubrava, School ofMedicine, University of Zagreb, Zagreb, Croatia
Petra Meliš
; Medical Department, University Hospital Dubrava, School ofMedicine, University of Zagreb, Zagreb, Croatia
Marko Lucijanić
; Medical Department, University Hospital Dubrava, School ofMedicine, University of Zagreb, Zagreb, Croatia
Ivica Grgurević
; Medical Department, University Hospital Dubrava, School ofMedicine, University of Zagreb, Zagreb, Croatia
Petra Turčić
; Department of Pharmacology and Biochemistry, Faculty of Pharmacyand Biochemistry, University ofZagreb, Zagreb, Croatia
Paulo Roque Obreli Neto
; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Brazil
Ines Bilić-Ćurčić
; Department of Diabetes, Endocrinology and Metabolism Disorders, Faculty of MedicineUniversity of Osijek, Osijek, Croatia
Sažetak
Aim To evaluate the impact of pharmacotherapeutic education
on 30-day post-discharge medication adherence
and adverse outcomes in patients with type 2 diabetes
mellitus (T2DM).
Methods The prospective, randomized, single-center
study was conducted at the Medical Department of University
Hospital Dubrava, Zagreb, between April and June
2018. One hundred and thirty adult patients with T2DM
who were discharged to the community were randomly
assigned to either the intervention or the control group.
Both groups during the hospital stay received the usual
diabetes education. The intervention group received additional
individual pre-discharge pharmacotherapeutic
education about the discharge prescriptions. Medication
adherence and occurrence of adverse outcomes (adverse
drug reactions, readmission, emergency department visits,
and death) were assessed at the follow-up visit, 30 days after
discharge.Results The number of adherent patients was significantly
higher in the intervention group (57/64 [89.9%] vs 41/61
[67.2%]; χ2 test, P = 0.003]. There was no significant difference
between the groups in the number of patients who
experienced adverse outcomes (31/64 [48.4%] vs 36/61
[59.0%]; χ2 test, P = 0.236). However, higher frequencies of
all adverse outcomes were consistently observed in the
control group.
Conclusion Pharmacotherapeutic education of patients
with T2DM can significantly improve 30-day post-discharge
medication adherence, without a significant reduction
in adverse clinical outcomes.
Ključne riječi
Hrčak ID:
239195
URI
Datum izdavanja:
16.12.2018.
Posjeta: 1.012 *