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Croatian Medical Journal, Vol. 60 No. 4, 2019.

Original scientific paper

https://doi.org/10.3325/cmj.2019.60.361

Association between rs2303861 polymorphism in CD82 gene and nonalcoholic fatty liver disease: a preliminary case-control study

Parham Habibzadeh ; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Behnam Honarvar ; 2Health Policy Research CenterInstitute of Health, Shiraz Universityof Medical Sciences, Shiraz, Iran
Mohammad Silawi ; Persian BayanGene Research and Training Center, Shiraz, Iran
Shima Bahramjahan ; Persian BayanGene Research and Training Center, Shiraz, Iran
Azar Kazemi ; Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Ali Faghihi ; Persian BayanGene Research and Training Center, Shiraz, Iran
Kamran Lankarani orcid id orcid.org/0000-0002-7524-9017 ; 2Health Policy Research CenterInstitute of Health, Shiraz Universityof Medical Sciences, Shiraz, Iran

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Abstract

Aim To investigate the genetic factors involved in the development
of non-alcoholic fatty liver disease (NAFLD) and
its sequelae in a Middle Eastern population.
Methods This genetic case-control association study, conducted
in 2018, enrolled 30 patients with NAFLD and 30
control individuals matched for age, sex, and body mass
index. After quality control measures, entire exonic regions
of 3654 genes associated with human diseases were sequenced.
Allelic association test and enrichment analysis
of the significant genetic variants were performed.
Results The association analysis was conducted on 27
NAFLD patients and 28 controls. When Bonferroni correction
was applied, NAFLD was significantly associated
with rs2303861, a variant located in the CD82 gene
(P = 2.49 × 10−7, adjusted P = 0.0059). When we used Benjamini-
Hochberg adjustment for correction, NAFLD was
significantly associated with six more variants. Enrichment
analysis of the genes corresponding to all the seven
variants showed significant enrichment for miR-193b-5p
(P = 0.00004, adjusted P = 0.00922).
Conclusion A variant on CD82 gene and a miR-193b expression
dysregulation may have a role in the development
and progression of NAFLD and its sequelae

Keywords

Hrčak ID:

240102

URI

https://hrcak.srce.hr/240102

Publication date:

15.8.2019.

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