Izvorni znanstveni članak

https://doi.org/10.37797/ig.39.4.2

Detection of IgG against Rickettsia typhi: a population-based study in southern Kazakhstan

Yuliya V. Perfilyeva ; Laboratory for expertise and diagnostics, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Anna S. Nizkorodova ; Laboratory of molecular biology, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Zhanna A. Berdygulova ; Laboratory of molecular biology, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Yekaterina O. Ostapchuk ; Laboratory of molecular biology, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Dinara A. Naizabayeva ; Laboratory for expertise and diagnostics, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Alena S. Neupokoyeva ; Laboratory for expertise and diagnostics, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Tatyana V. Kuznetsova ; Laboratory for expertise and diagnostics, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Tatyana S. Shishkina ; Museum of Living Cultures, Antiplaque Station, Shymkent, Kazakhstan
Gulzhan N. Abuova ; Department of Infectious Diseases, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Ravilya A. Yegemberdiyeva ; Department of Infectious and Tropic Diseases, Kazakh National Medical Academy after S. Asfendiyarov, Almaty, Kazakhstan
Akerke O. Bissenbay ; Department Biological Safety Control, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Elina R. Maltseva ; Department Biological Safety Control, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Seidigapbar M. Mamadaliyev ; Almaty Branch of the National Centre for Biotechnology, Almaty, Kazakhstan
Andrey M. Dmitrovsky ; Laboratory for expertise and diagnostics, Almaty branch of the National Centre for Biotechnology, Almaty, Kazakhstan

Sažetak

Background. Rickettsia typhi belongs to the typhus group of rickettsiae and causes endemic typhus. Cases of endemic typhus and seropositivity to R. typhi have been reported in the neighbouring China and Russia. However, little is known of the endemic typhus in Kazakhstan. The purpose of this study was to evaluate the prevalence of IgG antibodies to R. typhi in the population of southern region of Kazakhstan.
Methods. A total of 253 individuals (142 women, 111 men) aged from 1 to 71 years were recruited into the study. Detection of serum IgG antibodies against R. typhi was performed by enzyme-linked immunosorbent assay (ELISA).
Results. The overall R. typhi seropositivity has reached 34.4%. The highest seroprevalence of 91.8% was recorded in the Turkestan Region. The lowest seropositivity of 6.1% was detected in the village Lepsinsk, Almaty Region. The seroprevalence did not differ significantly between genders. Seropositivity in adult individuals was not significantly associated with age, but positive results were not detected in the age group of children under 14 years.
Conclusion. The obtained results confirm active circulation of R. typhi in the Turkestan and Almaty Regions of Kazakhstan. The data indicate an urgent need for further studies aimed to evaluate the clinical impact caused by R. typhi in the southern region of Kazakhstan.

Ključne riječi

Rickettsia typhi; Kazakhstan; IgG antibodies

Hrčak ID:

240692

URI

https://hrcak.srce.hr/240692

Datum izdavanja:

7.7.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.948 *