Veterinarski arhiv, Vol. 76 No. 6, 2006.
Izvorni znanstveni članak
Effect of E. coli lipopolysaccharides-induced fever on the disposition pattern of cefotaxime in buffalo calves
Suresh Kumar Sharma
; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural
Anil Kumar Srivastava
; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural
Milind Devidas Deore
; Bombay Veterinary College, Parel, Mumbai, India
Sažetak
The pharmacokinetics, urinary excretion and dosage regimen of cefotaxime after its single intravenous administration (10 mg/kg) was investigated in experimentally induced fever in buffalo calves (n = 5). The fever was induced by intravenous injection of E. coli lipopolysaccaride (1 μg/kg). At 1 min. the concentration of cefotaxime in plasma was 90.9 ± 2.85 μg/mL, which rapidly declined to 26.2 ± 1.05 μg/mL at 10 min. The drug was detected for up to 8 h. The elimination half-life and volume of distribution were 1.85 ± 0.11 hr and 1.70 ± 0.07 L/kg, respectively. The distribution half-life and area under curve (AUC) were 0.078 ± 0.003 hr and 15.8 ± 0.85 μg/mL.hr, respectively. Total body clearance (ClB) and tissue/plasma (T/C) ratio were 644 ± 39.2 mL/kg/h and 15.8 ± 1.04, respectively. Cefotaxime was bound to plasma proteins of febrile buffalo calves to the extent of 32.3 ± 1.86 per cent. To maintain a minimum therapeutic concentration of 1 μg/mL, a satisfactory dosage regimen of cefotaxime in febrile buffalo calves would be 17 mg/kg, followed by 15 mg/kg at 6 h. intervals.
Ključne riječi
buffalo calf; cefotaxime; dosage regimen; fever; pharmacokinetics; protein binding; urinary excretion
Hrčak ID:
22259
URI
Datum izdavanja:
20.12.2006.
Posjeta: 1.182 *