Veterinarski arhiv, Vol. 90 No. 4, 2020.
Izvorni znanstveni članak
https://doi.org/10.24099/vet.arhiv.0706
L-carnitine ameliorates immune-metabolic response and improves antioxidant status in goats with pregnancy toxemia
Maged R. El-Ashker
orcid.org/0000-0002-3217-9864
; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
Samia S. El-Demerdash
; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
Mohamed A. Youssef
; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
Sažetak
According to the literature, there have been limited studies describing the efficacy of L-carnitine (LC) administration in goats. The present study was designed to evaluate the influence of orally administered LC on some immune- metabolic variables, as well as the redox status in goats with experimentally induced pregnancy toxemia (PT). The study included eighteen clinically healthy Baladi goats at 110 ± 5 days of gestation. The animals were randomly allocated into three equally-sized groups: control, toxemic (PT), and toxemic treated with LC (TLC). On day 110 ± 5 of gestation, the goats in the TLC group received 10 mL of LC given as an oral drench once daily. Administration of LC was continued for 20 consecutive days. At day 130 of gestation, PT was experimentally induced in the animals of the PT and TLC groups by means of feed withdrawal for 72 hours. For biochemical analyses, blood samples were collected from each investigated doe via jugular vein puncture before PT induction (T0), and once daily for five consecutive days (T1, T2, T3, T4, and T5). The clinical findings of PT appeared in all the goats of the PT group after 72 hours of feed withdrawal, while the goats of the TLC group did not show any clinical symptoms throughout the study period. Administration of LC elicited initial and sustained low serum levels of malondialdehyde (MDA), tumor necrosis factor (TNF-α), and high serum glucose, superoxide dismutase (SOD) and interleukin (IL)-10 at T0 compared with those of the control and PT groups. At T3, goats that received LC showed significantly lower values of β-hydroxybutyric acid, non-esterified fatty acid, triacylglycerols, MDA, TNF-α, IL-1β, IL-6, and higher values of total cholesterol, glutathione peroxidase, SOD, and IL-10 than those of the PT group. Our data suggest that orally administered LC could be useful in ameliorating the immune status and improving lipid metabolism in goats with PT.
Ključne riječi
pregnancy toxemia; L-carnitine; cytokine; oxidative stress
Hrčak ID:
245188
URI
Datum izdavanja:
22.10.2020.
Posjeta: 943 *