Medicina, Vol. 56 No. 4, 2020.
Pregledni rad
https://doi.org/10.21860/medflum2020_245225
Epigenetic biomarkers in kidney transplantation
Klara Frančić
; Klinički zavod za transfuzijsku medicinu, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Nataša Katalinić
; Klinički zavod za transfuzijsku medicinu, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Sanja Balen
; Klinički zavod za transfuzijsku medicinu, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Sažetak
Currently used prognostic biomarkers in kidney transplantation are – crossmatch, serum creatinine concentration and evaluation of glomerular filtration rate, proteinuria and a histopathological analysis of graft biopsy. The development of genetics and new technologies has enabled the discovery of new biomarkers as early predictors of acute rejection response, delayed graft function, ischemia-reperfusion injury, interstitial fibrosis, tubular atrophy and long-term graft survival. Numerous studies have been conducted to examine the influence of environmental factors on human genome and its relation with the immune response in kidney transplantation. The aim of this article is to present potential epigenetic biomarkers – the products of epigenetic mechanisms, and their importance in the outcome of renal transplantation.
Ključne riječi
biomarkers; epigenetic processes; graft survival; renal transplantation
Hrčak ID:
245225
URI
Datum izdavanja:
1.12.2020.
Posjeta: 1.176 *