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URINARY IODINE CONCENTRATION: PREDICTOR OF BIRTH WEIGHT OR BIOMARKER FOR ASSESSING THE IODINE STATUS IN HEALTHY PREGNANT WOMEN, ONLY?
MAJA AVRAMOVSKA
orcid.org/0000-0003-1129-1205
; Klinička bolnica “Dr Trifun Panovski” – Bitola, Klinika za ginekologiju i opstetriciju, Bitola, Sjeverna Makedonija
BORISLAV KARANFILSKI
; Institut za patofi ziologiju i nuklearnu medicinu, Medicinski fakultet -Skopje, Sveučilište Sv. Ćirila i Metodija, Skopje, Sjeverna Makedonija
GORAN DIMITROV
; Klinika za ginekolgoiju i opstetriciju, Medicinski fakultet - Skopje, Sveučilište Sv. Ćirila i Metodija, Skopje, Sjeverna Makedonija
GLIGOR TOFOSKI
; Klinika za ginekolgoiju i opstetriciju, Medicinski fakultet - Skopje, Sveučilište Sv. Ćirila i Metodija, Skopje, Sjeverna Makedonija
ELENA DZIKOVA
; Klinika za ginekolgoiju i opstetriciju, Medicinski fakultet - Skopje, Sveučilište Sv. Ćirila i Metodija, Skopje, Sjeverna Makedonija
ANA DANEVA MARKOVA
; Klinika za ginekolgoiju i opstetriciju, Medicinski fakultet - Skopje, Sveučilište Sv. Ćirila i Metodija, Skopje, Sjeverna Makedonija
MARIJA HADZI-LEGA
; Danat Al Emarat Hospital for Women and Children, Abu Dhabi, Ujedinjeni Arapski Emirati
KOSTA SOTIROSKI
; Ekonomski fakultet – Prilep, Odjel za statistiku, Sveučilište St. Clement of Ohrid – Bitola, Sjeverna Makedonija
OLIVIJA VASKOVA
; Institut za patofi ziologiju i nuklearnu medicinu, Medicinski fakultet -Skopje, Sveučilište Sv. Ćirila i Metodija, Skopje, Sjeverna Makedonija
ALEKSANDAR SIKOLE
; Klinika za nefrologiju, Medicinski fakultet - Skopje, Sveučilište Sv. Ćirila i Metodija, Skopje, Sjeverna Makedonija
Sažetak
Introduction: This study determined urine iodine concentration (UIC) during gestation, assessed the maternal iodine nutrition status and correlated it with gestational age at birth (GAB) and birth weight (BW).The measurement of UIC provides the best single measurement of the iodine nutritional status in population. Objective: Determination of UIC in pregnant women in North Macedonia. Methods: This prospective study assessed the iodine nutrition status during the course of pregnancy with reference of median UIC among 364 healthy pregnant women in different gestational age (in trimester and 5-week intervals). Results: The overall and the 1st to the 3rd trimester median UIC were: 183.7, 207, 189.75 and 169.28 [μg/L], respectively. The median UIC (μg/L) results according to 5-week interval in advancing gestation were: 232.34, 200.13, 152.81, 194.39, 181.28, 160.28, 169.41 and 175.24, respectively. We detected 5.22% (19/364) and 74.72% (272/364) with
the median UIC < 50 μg/L and UIC ≥ 100 μg/L, respectively. In multiple regression, the median UIC (β = 0.0000767, P = 0.929) had no statistically signifi cant prediction to the GAB. Disease prevalence results for mean UIC in detecting BW had no statistical signifi cance: area under curve (AUC) = 0.521, z-statistic (0.340), sensitivity (45.83%), specifi city (66.27%), predictive (6.59%) and P value (0.734). Conclusion: Iodine status of pregnant women in our study is generally suffi cient by World Health Organization recommendations. The median UIC in each trimester and 5-week interval has statistically insignifi cant decrease in accordance to the advancing gestation. The median UIC has no signifi cance in predicting GAB and BW.
Ključne riječi
pregnancy; urinary iodine concentratio; iodine nutritional status; birth weight; gestational age at birth; thyroid metabolism
Hrčak ID:
245735
URI
Datum izdavanja:
6.11.2020.
Posjeta: 1.051 *