Izvorni znanstveni članak
https://doi.org/10.26332/seemedj.v4i2.145
The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients
Marina Hlavati
orcid.org/0000-0002-7931-2423
; Department for Diagnostic and Therapeutical Procedures-Neurology Unit, General Hospital Našice, Croatia; Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, Croatia
Svetlana Tomić
; Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, Croatia
Krunoslav Buljan
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
Silva Butković-Soldo
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
Sažetak
Introduction: Chronic obstructive pulmonary disease (COPD) is associated with an oxidant-antioxidant imbalance. COPD patients have impaired cerebral vasoreactivity (CVR). Impaired CVR could be correlated with total antioxidant status (TAS) in plasma.
Aim: To determine the role of systemic TAS in CVR of COPD patients.
Material and Methods: In this cross-sectional observational study, we included 120 participants (the mean age of 67±7.9, 87 males), 90 COPD patients categorized according to the severity of airway obstruction in mild, moderate, severe/very severe and 30 age- and sex-matched controls. We analyzed baseline mean flow velocities (MFV) of the middle cerebral artery (MCA) and the basilar artery (BA), the mean breath-holding index (BHIm) of those arteries (BHImMCA and BHImBA) by transcranial Doppler ultrasound and TAS in plasma. The level of significance was set to α=0.05.
Results: A significant negative correlation between TAS and BHImBA (Rho=−0.445, P=0.01) was found only in the mild COPD group. In COPD groups, baseline MFV BA is in a significant positive correlation with BHImMCA and BHImBA (Rho=0.336, P=0.001 and Rho=0.647, P<0.001). According to the severity of airway obstruction in COPD groups, a significant positive correlation between baseline MFV BA and BHImBA was found: in mild (Rho=0.731, P<0.001), moderate (Rho=0.574, P=0.001) and severe/very severe (Rho=0.398, P=0.03).
Conclusion: Systemic TAS was not correlated with CVR in all COPD groups. However, perfusion in the BA of COPD groups was in a significant positive correlation with the anterior and posterior CVR. The analysis of perfusion in the basal cerebral arteries should be part of a future study of CVR in COPD patients.
(Hlavati M, Tomić S, Buljan K, Butković-Soldo S. The Role of Total Antioxidant Status in Cerebral Vasoreactivity of Chronic Obstructive Pulmonary Disease Patients. SEEMEDJ 2020; 4(2); 48-61)
Ključne riječi
chronic obstructive pulmonary disease; antioxidants; transcranial Doppler ultrasonography; breath-holding; cerebral perfusion
Hrčak ID:
246201
URI
Datum izdavanja:
12.11.2020.
Posjeta: 517 *