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Synthesis of Some Quaternary Bases Related to Tropine. Studies in the Muscarine Series. V

N. Bregant ; Chemical Institute, Faculty of Science, University of Zagreb, Strossmayerov trg 14 , Zagreb, Croatia, Yugoslavia
J. Jančulev ; Chemical Institute, Faculty of Science, University of Zagreb, Strossmayerov trg 14 , Zagreb, Croatia, Yugoslavia
S. Ghyczy ; Chemical Institute, Faculty of Science, University of Zagreb, Strossmayerov trg 14 , Zagreb, Croatia, Yugoslavia

Sažetak

In connection with earlier work on muscarine from this laboratory the following compounds have been synthesized: from DL-tropinic acid dimethyl ester (I) 1-methyl-2-hydroxymethyl-5-(2 '-hydroxyethylpyrrolidine (II) and 1,1-dimethyl-2-hydroxymethyl-5-(2'-hydroxyethyl)pyrrolidinium iodide (III) were prepared; from 1,2,6-trimethyl-4-hydroxypiperidine and methyl iodide 1,1,2,6-tetramethyl-4-hydroxypiperidinium iodide (IV) was prepared; catalytic
hydrogention of 1-methyl-3-hydroxypyridone-(4) gave 1-methyl-3,4-dihydroxypiperidine, from which, by reacting with methyl iodide, 1,1-dimethyl-3,4-dihydroxypiperidinium iodide (V) was obtained.

Ključne riječi

Hrčak ID:

247905

URI

https://hrcak.srce.hr/247905

Datum izdavanja:

1.2.1956.

Posjeta: 548 *