Acta Pharmaceutica, Vol. 58 No. 3, 2008.
Kratko priopćenje
https://doi.org/10.2478/v10007-008-00011-6
2-Amino-5-sulfanyl-1,3,4-thidiazoles: A new series of selective cyclooxygenase-2 inhibitors
RAJESH SHARMA
JITENDRA SAINY
SUBHASH CHANDRA CHATURVEDI
Sažetak
A new series of cyclooxygenase-2 inhibitors with 2-amino-5-sulfanyl-1,3,4-thiadiazole as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for cyclooxygenase inhibitory activity by colorimetric COX (ovine) inhibitor screening assay, anti-inflammatory activity by the carrageenean induced rat paw oedema test and analgesic activity by the tail flick method. Some compounds exhibited significant biological activity.
Ključne riječi
2-amino-5-sulfanyl-1,3,4-thiadiazoles, cyclooxygenase-1; cyclooxygenase-2; anti-inflammatory activity; analgesic activity
Hrčak ID:
22932
URI
Datum izdavanja:
1.9.2008.
Posjeta: 2.635 *