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Some Alkylidene Derivatives of Isonicotinyl Hydrazine

N. Štimac ; Chemical Institute, Faculty of Science, University of Zagreb Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb. Croatia, Yugoslavia

Puni tekst: engleski pdf 2.330 Kb

str. 103-104

preuzimanja: 10



The remarkable in vivo activity of isonicotinyl hydraizine against M. tuberculosis1' 2 led to much searching for further tuberculoactive pyridine derivatives3. From these investigations it is evident, with regard to the hydrazides, that certain changes, such as the shifting of the hydrazide grouping from the gamma to the beta position resulted in total abolition of activity. When further exploring this field it was found that a great number of alkylidene derivatives of the 1-isonicotinyl-2-alkylidene hydrazine type were tuberculostatic in vivos.

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