Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2020.389

PERIPHERAL 8-ISO-PGF2α AS A BIOMARKER IN BOSNIAN PATIENTS WITH ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA

Orhan Lepara ; Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Asija Zaciragic ; Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Almir Fajkic ; Department of Pathophysiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Alma Dzubur Kulenovic ; Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Amela Dervisevic ; Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Amina Valjevac ; Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Emina Kiseljakovic ; Department of Medical Biochemistry, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Saida Ibragic ; Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

Sažetak

Background: Cerebrospinal levels of isoprostanes (IsoPs) have been established as biomarkers of oxidative stress in
Alzheimer’s disease (AD) and vascular dementia (VD). The value of peripheral levels in the diagnostics of these diseases is less conclusive. The aim of this study was to determine serum 8-iso-prostaglandin-F2alpha (8-iso-PGF2α) levels in Bosnian AD and VD patients and to establish whether there is an association between 8-iso-PGF2α serum concentration and cognitive impairment (CI) in patients with dementia.
Subjects and methods: Serum levels of 8-iso-PGF2α were measured by enzyme immunoassay method in AD (n=30) and VD
patients (n=30) and control subjects (CG, n=30). The AD and VD group were further stratified according to the level of CI.
Results: The serum 8-iso-PGF2α levels were significantly higher in the AD (74.00 pg/mL) and VD groups (38.00 pg/mL)
compared to the CG (17.50 pg/mL). A significant difference in serum 8-iso-PGF2α levels between patients with moderate and severe CI was not established in either AD or VD.
Conclusion: Serum 8-iso-PGF2α proved to be a good biomarker in AD and VD, however it cannot be recommended for the
differentiation of moderate and severe CI.

Ključne riječi

F2-Isoprostanes; oxidative stress; Alzheimer’s disease; vascular dementia; cognitive impairment

Hrčak ID:

250745

URI

https://hrcak.srce.hr/250745

Datum izdavanja:

7.1.2021.

Posjeta: 403 *