Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2021.158

OXIDATIVE STRESS AND SERUM S100B LEVELS IN ADOLESCENTS WITH FIRST-EPISODE DRUG-NAIVE UNIPOLAR DEPRESSION

Çilem Bilginer orcid.org/0000-0003-3375-3183 ; Karadeniz Technical University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Trabzon, Turkey
Hüseyin Yaman ; Karadeniz Technical University, Faculty of Medicine, Department of Biochemistry, Trabzon, Turkey
Serkan Karadeniz ; Avrasya University, Faculty of Health Science, Department of Child Development, Trabzon, Turkey
Sevda Hızarcı Bulut ; Karadeniz Technical University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Trabzon, Turkey
Serap Özer Yaman ; Karadeniz Technical University, Faculty of Medicine, Department of Biochemistry, Trabzon, Turkey
Sevil Aydoğdu ; Karadeniz Technical University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Trabzon, Turkey

Sažetak

Background: Unipolar depression is common among adolescents and has high recurrence rates. Studies conducted with adults
show that oxidative stress plays a role in etiology of depression but studies with adolescent patients are limited. In addition, baseline S100B level in adult patients with depression is considered as a marker of response to treatment. The purpose of this study was to measure the levels of serum S100B, Malondialdehyde (MDA), total oxidant status (TOS), and total antioxidant status (TAS), which have not been previously investigated in adolescent patients with first-episode, drug-naïve unipolar depression, and to investigate the relationship of these parameters with disease severity and patient-specific variables.
Subjects and methods: This study was conducted with 37 adolescents diagnosed with unipolar depression and 37 healthy peers. Participants were asked to fill out the Beck Depression Scale, Screen for Child Anxiety Related Disorders, and suicide probability questionnaires. After this procedure, 5 cc blood was collected from the adolescents and serum S100B, MDA, TOS, and OSI levels measured.
Results: Serum S100B, MDA, TOS, and OSI levels were higher and TAS level was lower in patients than their healthy peers. There was no relationship between the patients' severity of depression or suicide probability and these parameters. The serum S100B, MDA, TOS, and OSI levels of female patients were higher than their healthy peers, but the TAS level was not different. Male patients had higher TOS and OSI levels and lower TAS levels than their healthy peers.
Conclusions: The results show that increased serum S100B, MDA, TOS and OSI levels may contribute to etiology of depression regardless of gender. The gender-specific increase in S100B and MDA levels, which were significantly increased in female adolescent patients but not in males, should be supported by further follow-up studies.

Ključne riječi

unipolar depression; adolescent; S100B; oxidative stress; gender

Hrčak ID:

259544

URI

https://hrcak.srce.hr/259544

Datum izdavanja:

29.6.2021.

Posjeta: 425 *