Veterinarski arhiv, Vol. 78 No. 2, 2008.
Izvorni znanstveni članak
Role of co-administration of antioxidants in prevention of oxidative injury following sub-chronic exposure to arsenic in rats
Durgadas Nandi
; Environmental Medicine Laboratory, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India
Ramesh Chandra Patra
; Environmental Medicine Laboratory, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India
Rakesh Ranjan
; Environmental Medicine Laboratory, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India
Devendra Swarup
; Environmental Medicine Laboratory, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India
Sažetak
In this experiment thirty rats were exposed to 0 (Gr. I, healthy controls) or 10 ppm arsenic (sodium arsenite) through drinking water ad lib for eight weeks after dividing them into five groups of six rats each. Rats in Gr. III, IV and V were administered a daily oral dose of cysteine, methionine or ascorbic acid 25 mg/kg body mass respectively, while those in Gr. II served as the treated control. At the end of the experimental period oxidative stress indices viz. lipid peroxides level (LPO), superoxide dismutase (SOD) and catalase (CAT) activities were estimated in blood, liver and kidneys from sacrificed rats. Arsenic exposure resulted in a significant (P<0.05) rise in LPO levels and activities of SOD and CAT in erythrocytes, liver and kidneys. All the different treatments reduced lipid peroxides levels and restored activities of antioxidant enzymes to variable extents in various tissues. However, arsenic exposure did not show any significant (P>0.05) effects on the body mass of rats of different groups over time. It is concluded from the present study that prophylactic co-administration of cysteine, methionine and ascorbic acid could provide tissue specific protection from oxidative injury during sub-chronic exposure to arsenic
Ključne riječi
antioxidants; arsenic; ascorbic acid; cysteine; methionine; rat
Hrčak ID:
24142
URI
Datum izdavanja:
21.4.2008.
Posjeta: 1.357 *