Veterinarski arhiv, Vol. 78 No. 2, 2008.
Izvorni znanstveni članak
The rodenticidal effect of indomethacin: pathogenesis and pathology
Victor Olusegun Taiwo
; Department of Veterinary Pathology, University of Ibadan, Ibadan
Omotayo Lawal Conteh
; Department of Veterinary Pathology, University of Ibadan, Ibadan
Sažetak
The pathogenesis and pathology of the rodenticidal action of indomethacin, a non-steroidal antiinflammatory drug, were investigated. Sixteen Norway rats and 16 albino mice, aged 10-12 weeks with mean mass of 99.6 g and 28.4 g, respectively were divided into eight groups of 4 rats (R1, R2, R3 and R4) and 4 mice (M1, M2, M3 and M4). Rodents in R1 and M1 were controls (0 mg/kg indomethacin), while those in R2, R3, R4, and M2, M3, M4 were each given 83 mg/kg, 166 mg/kg and 250 mg/kg body mass of indomethacin orally, respectively. Clinical signs, symptoms and mortalities were monitored, while detailed postmortem examination was carried out. Indomethacin caused anorexia, dehydration and weakness, which became progressively worse with time; and there was 100% mortality within 36 and 82 hours in mice and rats, respectively. Seven rats (43.8%) were diarrheic, and had bilateral medial canthi haemorrhages. Gross lesions in all the rodents include congested and haemorrhagic stomach and intestinal mucosae, with focal areas of ulcerations, and focal pale areas on the liver. Histopathological changes in various organs were similar, irrespective of the animal species and dose of indomethacin, and include widespread congestion and haemorrhage, thrombi in arterioles and capillaries of the kidney, heart, lungs, brain, testes and splenic fat. There was widespread glandular degeneration and necrosis, erosions, ulcerations in the stomach and small intestines, renal glomerular and tubular degeneration, hepatocellular necrosis, myocardiac necrosis, testicular and neuronal degeneration. Indomethacin appears to cause widespread endothelial and mucosal damage, haemorrhage and vascular thrombosis, leading to ischaemic necrosis, with subsequent multiple organ failure and death. The mechanisms of action and implications of the
use of indomethacin as a rodenticide to domestic pets are discussed.
Ključne riječi
rodenticide; indomethacin; toxicoses; pathology; pathogenesis; rats; mice
Hrčak ID:
24148
URI
Datum izdavanja:
21.4.2008.
Posjeta: 14.316 *