Recenzija, Prikaz slučaja

A new case of transient hyperphosphatasemia in a 21 -month-old child with recurrent wheezing - case repor

Renata Zrinski-Topić orcid.org/0000-0002-3740-7854 ; Odjel za kliničko-laboratorijsku dijagnostiku, Dječja bolnica „Srebrnjak", Referentni centar Ministarstva zdravstva za kliničku alergologiju djece, Zagreb, Hrvatska
Miljenko Raos ; Odjel za pulmologiju i alergologiju dojenčadi i male djece, Dječja bolnica „Srebrnjak", Referentni centar Ministarstva zdravstva za kliničku alergologiju djece, Zagreb, Hrvatska
Jadranka Demirović ; Medicinsko-biokemijski laboratorij, Klinika za tumore, Zagreb, Hrvatska
Jadranka Živčić ; Odjel za kliničko-laboratorijsku dijagnostiku, Dječja bolnica „Srebrnjak", Referentni centar Ministarstva zdravstva za kliničku alergologiju djece, Zagreb, Hrvatska
Ivana Čepelak ; Zavod za medicinsku biokemiju i hematologiju, Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Rajka Petrinović ; Medicinsko-biokemijski laboratorij, Klinika za tumore, Zagreb, Hrvatska
Slavica Dodig ; Odjel za kliničko-laboratorijsku dijagnostiku, Dječja bolnica „Srebrnjak", Referentni centar Ministarstva zdravstva za kliničku alergologiju djece, Zagreb, Hrvatska

Sažetak

Introduction: A case of transient hyperphosphatasemia in a 21-month-old boy diagnosed with recurrent wheezing during acute respiratory infection is described.
Materials and methods: Determination of alkaline phosphatase catalytic activity was performed by the recommended photometric method, and elec-trophoretic separation of alkaline phosphatase isoenzymes on agarose gel by serum processing with lectin.
Results: During hospital treatment, increased catalytic activity of alkaline phosphatase was recorded (4109 U/L on day 1 and 2156 U/L on day 6). On control examination on day 27 of hospital admission, the value decreased to 505 U/L. Electrophoretic separation of alkaline phosphatase isoenzymes demonstrated a band faster than the hepatic-osseous isoenzyme, a fast anodal form.
Conclusion: A marked increase in the alkaline phosphatase catalytic activity with typical electrophoretic isoenzyme pattern persisting for several weeks points to transient hyperphosphatasemia. Additional unnecessary diagnostic work-up can be obviated by timely recognition of the phenomenon.

Ključne riječi

hyperphosphatasemia; alkalinephosphatase; isoenzymes; wheezing; infant

Hrčak ID:

24163

URI

https://hrcak.srce.hr/24163

Datum izdavanja:

5.6.2008.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.525 *