Kratko priopćenje

https://doi.org/10.2478/acph-2022-0012

Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits

LIDIJA CHAKULESKA LIDIJA CHAKULESKA ; Department of Pharmacology, harmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria
ALEKSANDAR SHKONDROV ; Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria
GEORGI POPOV ; Department of Internal Non-infectious Diseases, Pathology and Pharmacology, Faculty of Veterinary Medicine, University of Forestry 10, 1756 Sofia, Bulgaria
NADYA ZLATEVA-PANAYOTOVA ; Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Forestry, 10, 1756 Sofia, Bulgaria
RENETA PETROVA ; National Diagnostic and Research Veterinary Institute, Department: National Center of Animal Health, Sofia, Bulgaria
MARIYANA ATANASOVA ; Department of Chemistry, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria
ILINA KRASTEVA ; Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria
IRINI DOYTCHINOVA ; Department of Chemistry, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria
RUMYANA SIMEONOVA orcid.org/0000-0003-4860-9053 ; Department of Pharmacology, harmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria

Sažetak

Sophora japonica is a source of several flavonol, flavone and isoflavone glycosides that are reported to positively affect menopausal symptoms including osteoporotic complications. In the present study fructus Sophorae extract (FSE) was administered orally for three months at a dose of 200 mg kg–1 in ovariectomized (OVX) New Zealand rabbits. 3D computed tomography scans and histopathological images revealed microstructural disturbances in the bones of the castrated animals. FSE recovered most of the affected parameters in bones in a manner similar to zoledronic acid (ZA) used as a positive control. The aglycones of the main active compounds of FSE, daidzin, and genistin, were docked into the alpha and beta estrogen receptors and stable complexes were found. The findings of this study provide an insight into the effects of FSE on bone tissue loss and suggest that it could be further developed as a potential candidate for the prevention of postmenopausal osteoporotic complications.

Ključne riječi

osteoporosis; Sophora japonica fruits; ovariectomized rabbits; molecular docking; estrogen receptors

Hrčak ID:

262129

URI

https://hrcak.srce.hr/262129

Datum izdavanja:

30.6.2022.

Posjeta: 1.091 *