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META-ANALYSIS OF MEDICAL AND NON-MEDICAL TREATMENTS OF THE PRODROMAL PHASE OF PSYCHOTIC ILLNESS IN AT-RISK MENTAL STATES
Christopher Kelly
; University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Hills Road, Cambridge, UK
Andreas V. Hadjinicolaou
; University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Hills Road, Cambridge, U
Clare Holt
; Fundation Programme East Anglian Deanery, UK
Mark Agius
; South Essex Partnership University Foundation NHS Trust, UK ;Bedfordshire Centre for Mental Health Research in Association with Cambridge University, UK ;Department of Psychiatry, University of Cambridge, UK
Rashid Zaman Zaman
; South Essex Partnership University Foundation NHS Trust, UK ;Bedfordshire Centre for Mental Health Research in Association with Cambridge University, UK ;Department of Psychiatry, University of Cambridge, UK
Sažetak
Introduction: There are now many existing studies which assess the treatments available for ‘at risk mental states’, as patients
who are believed to be in the prodromal phase of psychotic illness are referred to. However, concerns regarding side effects of
possible treatments remain.
We here conduct a meta-analysis of the studies available up to October 2010. The aim of this study is to decide what would be
the best treatment for ‘at high risk patients’.
Results: All the available studies examining potential treatments during the prodromal phase of psychotic illness were collected.
They all showed comparable efficacy, which reached statistical significance, excluding the one study using olanzapine, which in fact
‘tended towards significance’.
Discussion: Treatments appear promising but a balance needs to be kept between adverse events and effectiveness of preventing
psychosis.
Conclusion: It is necessary to search further for treatments in order to identify effective treatments with fewer adverse side
effects in this phase of psychotic illness.
Ključne riječi
at risk mental state; anti-psychotics; anti-depressants; Omega3 poly-unsaturated fatty acids; cognitive behaviour therapy
Hrčak ID:
262375
URI
Datum izdavanja:
14.9.2010.
Posjeta: 265 *