Izlaganje sa skupa
ADULT NEUROGENESIS AND DEPRESSION: AN INTRODUCTION
Michael James Gilhooley
; Southern General Hospital, Govan, Glasgow, UK
Sažetak
The following essay provides a summary of a seminar given on the sixth of November, 2010 at the combined annual congress,
held at Brussels of the Centro Studi Psichatrici Vrije Universiteit Brussel, Université Catholique de Louvain & the Bedfordshire
Centre for Mental Health Research. The talk aimed to present a brief taster, assuming no prior knowledge, of adult neurogenesis, the
formation of new nerve cells, in relation to the aetiology and treatment of depression.
The talk begins with an introduction to the principles of adult neurogenesis: from initial investigations by Ramon y Cajal in the
19th century, resulting in a "static brain hypothesis", to their subsequent challenge almost one hundred years later. The potential
functional implications emerging, especially in relation to depression, are explored. The fascinating effects of corticosteroids and
antidepressants are used as examples to explore the possible roles of neurogenesis that have led some to propose a neurogenic
theory of depression. Arguments against this theory are then presented. Finally, a consideration of future opinion: could
neurogenesis be less important in the aetiology of depression, but involved in its treatment - a property of antidepressant action
rather than a central final aetiological pathway.
In this young branch of neuroscience controversy abounds: our understanding of the process itself, its relations and most
importantly its implications are all in their infancy. This has allowed for some of the most interesting debate of recent years as to the
neurological basis and treatment of affective disorders.
Ključne riječi
Hrčak ID:
262380
URI
Datum izdavanja:
14.9.2010.
Posjeta: 483 *