Izlaganje sa skupa
DEMENTIA RISK ASSESSMENT AND RISK REDUCTION USING CARDIOVASCULAR RISK FACTORS
Anna McKeever
; University of Cambridge School of Clinical Medicine, Cambridge, UK
Mark Agius
; Department of Psychiatry, University of Cambridge, Cambridge, UK; Clare College, University of Cambridge, Cambridge, UK
Sažetak
Given the poor efficacy of disease modifying treatments and evidence that Alzheimer’s Disease (AD) pathophysiology begins in
middle-age, efforts to reduce the substantial disease burden have shifted towards preventative intervention in midlife. Up to a third of all AD(the commonest cause of dementia) is attributable to modifiable cardiovascular risk factors. A tool for predicting risk of future dementia using only cardiovascular risk factors has been validated and the effect of lifestyle modification on future cognitive decline is under investigation. In the UK, the QRISK3 risk calculator is used to quantify 10-year risk of cardiovascular disease. Lifestyle changes and lipid modifying therapy are recommended to patients based on their risk score. We will compare the emerging evidence for dementia risk assessment and risk reduction using cardiovascular risk factors with the evidence used to support the implementation of QRISK3 for cardiovascular disease risk assessment and intervention. This will guide future research to determine whether cardiovascular risk assessment can also be used to inform patients of risk of future dementia and advise on risk reduction strategies, in a primary care setting.
Ključne riječi
Alzheimer’s disease; dementia; screening; primary prevention
Hrčak ID:
262971
URI
Datum izdavanja:
21.11.2018.
Posjeta: 636 *