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THE IMMUNOMODULATORY EFFECT OF KETAMINE IN DEPRESSION

Łukasz P. Szałach ; Department of Physiopathology, Faculty of Medicine, Medical University of Gdańsk, Poland ;Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland
Katarzyna A. Lisowska ; Department of Physiopathology, Faculty of Medicine, Medical University of Gdańsk, Poland
Jakub Słupski ; Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland
Adam Włodarczyk ; Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland
Natalia Górska ; Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland
Joanna Szarmach ; Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland
Katarzyna Jakuszkowiak-Wojten ; Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland
Maria Gałuszko-Węgielnik ; Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland
Mariusz Stanisław Wiglusz ; Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland
Alina Wilkowska ; Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland
Wiesław J. Cubała ; Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland

Sažetak

Major depression is one of the most frequent psychiatric conditions. Despite many available treatment methods, more than 30%
of patients do not achieve remission, even after trying several antidepressants and augmentation strategies. S-enantiomer of
ketamine, well-known anesthetic and analgesic, has been recently approved by Food and Drug Administration in the intranasal form
as a new generation antidepressant. However, the mechanism in which ketamine reduces depressive symptoms in treatment-resistant
depression patients is still not completely understood. There are several theories explaining how ketamine might reduce depressive
symptoms, which have been described in detail; one of them is immunomodulatory effect of ketamine, according to the inflammatory
theory of depression. In the review authors present and summarize studies showing ketamine effect on human immune system ex vivo
and in vitro, including changes in cytokine levels, number, ratio and activity of various immune cell population and the correlation
with clinical improvement in depressive symptoms. Most of the results confirm the anti-inflammatory effect of ketamine. There are
only a few studies in the population of patients suffering from depression receiving ketamine, focused on correlation between
immunological changes and clinical outcome of the therapy; further studies of that area are neccesary for understanding the
immunomodulatory effect of ketamine in depression.

Ključne riječi

ketamine; depression; inflammation; cytokines; lymphocytes

Hrčak ID:

263310

URI

https://hrcak.srce.hr/263310

Datum izdavanja:

4.9.2019.

Posjeta: 312 *