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THE PREVALENCE OF LYME DISEASE AND ASSOCIATED CO-INFECTIONS IN PEOPLE WITH A CHRONIC POST-CONCUSSIVE SYNDROME
Sergio Azzolino
; Department of Neurology, Carrick Institute, Cape Canaveral, FL, USA ;GCSRT, Harvard Medical School, Boston, MA, USA
Rashid Zaman
; Centre for Mental Health Research in association with University of Cambridge (CMHR-CU), Cambridge, UK ;Hertfordshire Partnership University NHS Foundation Trust, UK ;Department of Psychiatry, University of Cambridge, Cambridge, UK
Ahmed Hankir
; GCSRT, Harvard Medical School, Boston, MA, USA ;Centre for Mental Health Research in association with University of Cambridge (CMHR-CU), Cambridge, UK, ;Department of Psychiatry, Carrick Institute for Graduate Studies, Cape Canaveral, FL, USA ;South London and Maudsley NHS Foundation Trust, London, UK
Frederick R Carrick
; Department of Neurology, Carrick Institute, Cape Canaveral, FL, USA ;GCSRT, Harvard Medical School, Boston, MA, USA ;Centre for Mental Health Research in association with University of Cambridge (CMHR-CU), Cambridge, UK, ;Department of Neurology, University of Central Florida College of Medicine, Orlando, FL, USA ;Department of Health Professions Education, MGH Institute of Health Professions, Boston, MA, USA
Sažetak
Introduction: There is increasing awareness that Lyme borreliosis (LB) and traumatic brain injury (TBI) may cause mental
health symptoms. TBI and Lyme disease compromise the health and activities of millions of patients per year. The chronic symptoms
and disability of TBI and Lyme disease share a similar clinical presentation. We have identified an alarming number of individuals
suffering from post-concussion syndrome (PCS) that are refractory to care and that have serologically tested positive for Lyme
disease.
Subject and methods: A single-center retrospective review of patient charts that were symptomatic a minimum of one year after
a TBI that were tested for Lyme disease to ascertain if there was a relationship.
Results: 217 PCS patient records (93 females with a mean age of 34 years, 120 males with a mean age of 40 years and 4
individuals with unknown gender) were included in the review. 38% had a positive Western Blot Igenex IgM. There was a
statistically significant relationship of a positive Western Blot Igenex IGM predicting chronic PCS Pearson χ2(1)=6.8866, P=0.009,
Fisher’s exact score p=0.015 and φ=0.2813 representing a moderate effect size.
Conclusions: Long term PCS over one year’s duration is associated with undiagnosed Lyme disease. There was statistical and
substantive significance between individuals with chronic PCS having a positive Western Blot Igenex IgM. Males were more likely to
have a positive Western Blot Igenex IgM than females.
Ključne riječi
Lyme disease; traumatic brain injury; post-concussion syndrome , mental illness
Hrčak ID:
263319
URI
Datum izdavanja:
4.9.2019.
Posjeta: 327 *