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Psychiatria Danubina, Vol. 29 No. suppl. 3, 2017.

Izlaganje sa skupa

LITHIUM THERAPEUTIC DOSE MONITORING IN HUMAN SALIVA

Maria Galuszko-Wegielnik ; Department of Psychiatry, Medical University of Gdansk, Poland
Katarzyna Jakuszkowiak-Wojten ; Department of Psychiatry, Medical University of Gdansk, Poland
Mariusz Stanislaw Wiglusz ; Department of Psychiatry, Medical University of Gdansk, Poland
Joanna Szarmach ; Department of Psychiatry, Medical University of Gdansk, Poland
Adam Wlodarczyk ; Department of Psychiatry, Medical University of Gdansk, Poland
Marta Herstowska ; Department of Psychiatry, Medical University of Gdansk, Poland
Wieslaw Jerzy Cubala ; Department of Psychiatry, Medical University of Gdansk, Poland

Puni tekst: engleski pdf 138 Kb

str. 361-364

preuzimanja: 103

citiraj

Sažetak

Background: Lithium carbonate is valuable and effective agent in the treatment and prophylaxis of mood disorders, particularly
bipolar disorder (BD). Due to its narrow therapeutic range, frequent serum lithium estimation is necessary. To avoid the discomfort of frequent venipuncture, a non-invasive method for serum lithium concentration is needed. An alternative method of determining lithium level could be saliva or urine. Literature data regarding the reliability of saliva lithium levels is not conclusive.
Material and methods: The aim of this study is to provide an overview of possibility to replace blood serum with saliva look
through research in that field.
Results: Some authors conclude that there is constant ratio between serum and saliva lithium level and they suggest that saliva
can replace serum for estimation lithium level. Other revealed that saliva/serum lithium ratio is constant individually, so saliva/serum lithium ratio should be estimated individually. Finally there are studies excluding the possibility of replacement serum with saliva.
Conclusions: There is little number of studies on saliva clinical use in lithium level monitoring. Further studies should base on
current data including methods of obtaining saliva and its biochemical analysis, collecting samples in a specific time frame from the last dosage of lithium, as well as inter-subject or intra-subject measurements.

Ključne riječi

monitored therapy; lithium carbonate; bipolar disorder; saliva

Hrčak ID:

263722

URI

https://hrcak.srce.hr/263722

Datum izdavanja:

15.6.2017.

Posjeta: 233 *