Izlaganje sa skupa
SHORT-TERM KETAMINE ADMINISTRATION IN TREATMENT-RESISTANT DEPRESSION: FOCUS ON CARDIOVASCULAR SAFETY
Joanna Szarmach
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdańsk, Poland
Wiesław Jerzy Cubała
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdańsk, Poland
Adam Włodarczyk
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdańsk, Poland
Mariusz S. Wiglusz
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdańsk, Poland
Sažetak
Ketamine is an anaesthetic and analgesic agent that demonstrates the antidepressive effect in major depression. Several
administrations routes, dosing schemas and esketamine are investigated in basic and clinical research with particular focus on
treatment-resistant depression (TRD) where drug demonstrates its efficacy where very limited alternatives are available. The
majority of ketamine studies in TRD treatment reported no serious adverse events regardless the administration route or regimen.
However, the most commonly observed adverse events following ketamine administration in antidepressive doses include general,
psychotomimetic, dissociative and hemodynamic ones. The side effects are mild or moderate, well-tolerated and transient.
This paper discusses the risks regarding cardiovascular safety in MDD patients in short-term ketamine administration with
particular focus on the effect on blood pressure and adverse drug reactions mitigation measures.
The increase in systolic (SBP) and diastolic (DBP) blood pressure is dose-dependent and begins shortly after administration
peaking at around 30 to 50 minutes with SBP and DBP rise from 10% to 50% above predose values and resolving at approximately
2 to 4 hours after the dose administration. These changes generally are primarily asymptomatic. The elevations in SBP and DBP are
observed on each dosing day with multiple administration schema.
The treatment with ketamine and esketamine is contradicted in subjects at risk of an increase in blood pressure or intracranial
pressure. The current evidence indicates the blood pressure should be assessed prior to dosing with ketamine and hypertensive individuals
shall receive effective lifestyle/pharmacologic management prior to treatment. Blood pressure should be monitored after dose
administration until blood pressure returns to acceptable levels. If blood pressure remains elevated acute blood pressure management
shall be delivered. In patients experiencing symptoms of hypertensive crisis immediate emergency care must be provided.
The unmet need for improved pharmacotherapies for TRD means the use of ketamine and esketamine is warranted therapeutic
option in patients who fail to achieve a sustained remission of depressive symptoms with drugs with monoamine-based mechanisms
of action. Adequate safety measures must be applied when using ketamine/esketamine in TRD subjects with particular focus on
somatic comorbidities as the transient drug effect on cardiovascular system is demonstrated and of clinical significance.
Ključne riječi
ketamine; MDD; treatment resistant depression; cardiovascular system; safety; adverse drug reactions; blood pressure
Hrčak ID:
264178
URI
Datum izdavanja:
4.9.2019.
Posjeta: 886 *