Izlaganje sa skupa
MANAGEMENT OF MARKED LIVER ENZYME INCREASE DURING OLANZAPINE TREATMENT: A CASE REPORT AND REVIEW OF THE LITERATURE
Pauline Manceaux
; Université Catholique de Louvain, 5530 Yvoir, Belgium
Eric Constant
; Université Catholique de Louvain, 5530 Yvoir, Belgium
Nicolas Zdanowicz
; Université Catholique de Louvain, 5530 Yvoir, Belgium
Denis Jacques
; Université Catholique de Louvain, 5530 Yvoir, Belgium
Christing Reynaert
; Université Catholique de Louvain, 5530 Yvoir, Belgium
Sažetak
Objectives: Atypical antipsychotics commonly cause isolated asymptomatic increase in the aminotransferase levels.
Furthermore, the strategy in the choice of antipsychotic agent must take into account hepatic tolerance because of the non-negligible
incidence of liver disorders among the psychiatric population. The aim of this article is to better understand the strategy to adopt
during an increase of liver enzymes in a psychotic patient under atypical neuroleptic treatment.
Method: A clinical case is presented of a female patient treated for psychotic decompensation with increase of liver enzymes
(Olanzapine). Her treatment was changed several times over a period of 7 years and labatory investigations were conducted
simultaneously .
Results: it seems that the increase of liver enzymes is slightly more frequent with Clozapine and Olanzapine than Risperidone,
Perazine and Haloperiol.
Conclusion: the different mechanisms of hepatotoxicity are unknown at present but it seems that the hypersensibility mechanism
is likely to be dose dependent. During an increase of enzymes, it is important to combine a control of hepatic enzymes with a
reduction of neuroleptic dosage. Discontinuation should be considered if a continued increase of enzymes above certain values is
shown or if a clinical symptom appears. We note also that some risk factors were found, including geriatric or pedopsychiatric age,
obesity, and association with active ingredients or addictive substances responsible for hepatic disorders.
Ključne riječi
antipsychotic drug; side effect; olanzapine; hepatic tolerance
Hrčak ID:
264648
URI
Datum izdavanja:
1.9.2011.
Posjeta: 486 *