Izlaganje sa skupa
ADOLESCENTS AND YOUNG ADULTS AT ULTRAHIGH RISK OF PSYCHOSIS: DETECTION, PREDICTION AND TREATMENT. A REVIEW OF CURRENT KNOWLEDGE
Laurence Mees
; MedicineFaculty, Université Catholique de Louvain, Psychopathology and Psychosomatic Unit, Clinique de Mont-Godinne, 5530 Yvoir, Belgium
Nicolas Zdanowicz
; MedicineFaculty, Université Catholique de Louvain, Psychopathology and Psychosomatic Unit, Clinique de Mont-Godinne, 5530 Yvoir, Belgium
Christine Reynaert
; MedicineFaculty, Université Catholique de Louvain, Psychopathology and Psychosomatic Unit, Clinique de Mont-Godinne, 5530 Yvoir, Belgium
Denis Jacques
; MedicineFaculty, Université Catholique de Louvain, Psychopathology and Psychosomatic Unit, Clinique de Mont-Godinne, 5530 Yvoir, Belgium
Sažetak
Background: The onset of psychosis is mostly preceded by a prodromal phase in which occur a series of various attenuated
positive symptoms, negative symptoms and functional impairment. Recently, several longitudinal studies have evaluated the validity
and prediction power of the “prodromal risk syndrome for psychosis”, which could lead to a better focused management of the
patients at real risk of developing schizophrenia. At the same time, several authors have studied the pharmacological and nonpharmacological
interventions for people at ultrahigh risk.
Methods and aims: The objective of this review is to establish the status of our current knowledge about what is the most
sensitive and specific tool to predict high risk of psychosis in the young population and which treatments have currently proved to be
the most effective in the risk versus benefits balance. We will try to answer to these questions by reviewing the international
literature from 2005 until today.
Results: Recent studies show significant improvement in the identification of individuals at high risk of developing psychosis,
using validated detection scales such as SIPS and CAARMS, multivariate neuroanatomical pattern classification and specific genetic
factors. Cognitive Behavioral therapy, approach improving social functioning, and Long-Chain Ω-3 Fatty Acids appears to be
promising alternatives to antipsychotics, for which the balance between benefice and adverse side effects seems questionable.
Conclusions: Detection of young people at ultrahigh risk of psychosis has significantly improved during the last 6 years. The
challenge for the next decade will be to define a nosologic entity specific and sensitive enough to become a diagnostic category by
itself, which could lead to specific guidelines for the preventive management of psychosis.
Ključne riječi
“Prodromal” patients; ultra high-risk; psychosis; prevention; early detection; treatment practice; early intervention
Hrčak ID:
264694
URI
Datum izdavanja:
1.9.2011.
Posjeta: 235 *