Izlaganje sa skupa
DISCOVERING NEW GENETIC AND PSYCHOSOCIAL PATHWAYS IN MAJOR DEPRESSIVE DISORDER: THE NEWMOOD PROJECT
Annabel Freeborough
; The Neuroscience and Psychiatry Unit. The University of Manchester, UK
Jessica Kimpton
; The Neuroscience and Psychiatry Unit. The University of Manchester, UK
Sažetak
The World Health Organisation predicts that Major Depressive Disorder (MDD) will be the second greatest contributor to the
global burden of disease by 2020, however, the neurobiological mechanisms behind the disease and the risk factors for it are yet
unknown. NewMood (New Molecules for Mood Disorders) was a research project funded by the EU, collaborating work from 10
European countries with the aim of finding new molecular mechanisms behind MDD to develop more effective treatment options.
This review explains the aims and objectives of NewMood and how it intends to achieve them with regards to the current
literature. It also outlines two of its most recent projects: genome wide association replication study for single nucleotide
polymorphisms (SNPs) increasing susceptibility to MDD and stress related pathways in depression using the cortisol awakening
response (CAR). Both of these studies had significant results and could further contribute to our current understanding of MDD.
Ključne riječi
depression; anti-depressants; molecular mechanisms; stress; single nucleotide polymorphisms
Hrčak ID:
264703
URI
Datum izdavanja:
1.9.2011.
Posjeta: 242 *