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EPIDEMIOLOGICAL CHARACTERISTICS OF CHILDREN BORN ITH DOWN SYNDROME IN WESTERN HERZEGOVINA IN THE PERIOD OF THE LAST TWENTY YEARS (1994-2013)
Darinka Šumanović-Glamuzina
; Clinic for Child Diseases, University Hospital Mostar, Bosnia and Herzegovina
Ana Zovko
; Clinic for Child Diseases, University Hospital Mostar, Bosnia and Herzegovina
Ivona Letica
; Clinic for Child Diseases, University Hospital Mostar, Bosnia and Herzegovina
Marjana Jerković-Raguž
; Clinic for Child Diseases, University Hospital Mostar, Bosnia and Herzegovina
Antonija Mustapić
; Clinic for Child Diseases, University Hospital Mostar, Bosnia and Herzegovina
Tomica Božić
; Clinic for Child Diseases, University Hospital Mostar, Bosnia and Herzegovina
Mladenka Vukojević
; Department for Psychophysiological Disoders, Medical Health Center, Mostar, Bosnia and Herzegovina
Sažetak
Background: Children with Down syndrome (DS) are an everyday casuistry of pediatric clinical medicine.
The prevalence of DS is dependent on socio-demographic and cultural conditions of a community. Antenatal screening is not
carried out mainly due to religious views, and the prevalence of DS in our region is really considered a "natural phenomenon“.
The aim of the study was to analyze some epidemiological characteristics of infants with Down syndrome in the western region of
Herzegovina in the period between year 1994-2013.
Subjects and methods: We performed a retrospective analysis of hospital records of children who were supervised and treated at
Children's Hospital through the twenty-year period.
Results: In this period there were 44,100 liveborn infants. Down syndrome was detected in 78 children (54 male and 24 female).
The prevalence is estimated at 1.8/1,000 of live births. Aborted fetuses and stillbirths were not analyzed. 37 (47%) of the parent
couples were over 35 years of age. Out of that 65 cytogenetic analysis, a regular type of trisomy 21 was found in 94% of cases, and
the translocation in 6%. From major malformations (MM) heart failure was more often present (47%), then the anomaly of the
gastrointestinal and genitourinary systems. Ten children (12%) died, most often in the early period of infancy due to complications of
the cardiovascular system.
Conclusion: The prevalence of DS throughout these two decades has been uniform in the region of western Herzegovina.
Improvement in perinatal care in recent years caused higher survival and a better quality of life for the children with DS and thus
their families. DS is less a desirable family tragedy, and increasingly a tolerable family fate.
Ključne riječi
Down syndrome; major malformations; epidemiology; prevalence; religiuos attitude
Hrčak ID:
265251
URI
Datum izdavanja:
5.11.2014.
Posjeta: 247 *