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Platelet Serotonin and Monoamine Oxidase in Alzheimer’s Disease with Psychotic Features

Ninoslav Mimica
Dorotea Mück-Šeler
Nela Pivac
Maja Mustapić
Martina Deželjin
Tamara Stipčević
Paola Presečki
Elizabeta Radonić
Vera Folnegović-Šmalc


Puni tekst: engleski pdf 103 Kb

str. 119-122

preuzimanja: 616

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Sažetak

Post mortem brain studies indicate that alterations in serotonergic and catecholaminergic systems might be associated
with Alzheimer’s disease (AD). The aim of the study was to determine serotonin (5-HT) levels and monoamine
oxidase type B (MAO-B) activity in platelets of psychotic and non-psychotic patients with AD, established according to the
NINCDS-ADRDA and DSM-IV-TR criteria. Cognitive impairment and psychotic features were evaluated using Mini
Mental Status Examination and Neuropsychiatric Inventory. Platelet 5-HT concentration and MAO-B activity were determined
spectrofluorimetrically in 116 (51 male, 65 female) healthy subjects and 70 psychotic (10 male, 60 female) and
151 non-psychotic (32 male, 119 female) patients. Psychotic and non-psychotic female and psychotic male patients had
significantly lower platelet 5-HT concentration than corresponding sex matched control subjects. Platelet MAO-B activity
was significantly increased in both male and female non-psychotic patients compared to the sex matched controls.
Non-psychotic female patients had significantly higher platelet MAO-B activity than psychotic female patients. Our data
suggest that platelet MAO-B activity, but not platelet 5-HT concentration, could differentiate between psychotic and non-
-psychotic subtypes of AD.

Ključne riječi

platelets; serotonin; monoamine oxidase; Alzheimer’s disease; psychotic features

Hrčak ID:

24564

URI

https://hrcak.srce.hr/24564

Datum izdavanja:

13.5.2008.

Posjeta: 1.195 *