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https://doi.org/10.2478/10004-1254-59-2008-1860

Biliary Function in Workers Occupationally Exposed to Aluminium Dust and Fumes

Milka Bogdanović ; Institute of Occupational Health “Dr Dragomir Karajović”, Belgrade, Serbia
Petar Bulat ; Institute of Occupational Health “Dr Dragomir Karajović”, Belgrade, Serbia


Puni tekst: engleski pdf 65 Kb

str. 135-139

preuzimanja: 754

citiraj


Sažetak

This study investigated billiary secretory function in workers occupationally exposed to aluminium dust and fumes. It included a group of 34 male workers aged (44.1±7.8) years and exposed up to 4.6 mg m-3 of aluminium dust and fumes in workplace air for (21.6±2.5) years, and a group of 30 unexposed control male workers. Serum and urine aluminium levels were measured in both groups before and after chelating treatment with 1 g deferoxamine by intramuscular injection. Billiary function was assessed by measuring gamma-glutamyl transpeptidase, alkaline phosphatase, 5-nucleotidase, cholesterol and its fractions, total and indirect bilirubin, and bile acids. We then analysed the relationship between Al exposure and billiary function. In the exposed group mean serum aluminium was significantly higher [(4.91±3.86) µg L-1] than in controls. The same was true for urine Al before [(1.57±1.93) µg L-1] and after deferoxamine [(11.51±14.97) µg L-1]. Total and indirect bilirubin and alkaline phosphatase were significantly higher in the exposed than in control workers, and they correlated with urine Al after the chelating treatment. Our findings suggest that chronic occupational exposure to aluminium dust and fumes leads to a significant body retention of aluminium. The impaired biliary secretion in the exposed workers manifested itself in subclinical signs of cholestasis.

Ključne riječi

aluminium, hepatic secretory function, occupational exposure

Hrčak ID:

24822

URI

https://hrcak.srce.hr/24822

Podaci na drugim jezicima: hrvatski

Posjeta: 1.483 *