Izvorni znanstveni članak
Gender differences in risk factors and cardiovascular outcomes in symptomatic peripheral artery disease patients
Mislav Vrsalović
Tonći Batinić
Nikola Kos
Sažetak
AIM: To compare the influence of gender on adverse cardiovascular events in patients with sympto- matic peripheral artery disease (PAD) based on their clinical presentation (intermittent claudication or critical limb ischemia, CLI).
PATIENTS AND METHODS: A prospective, registry-based study involving patients with symp- tomatic peripheral artery disease was conducted. Patients were divided according to initial clinical presentation (intermittent claudication or CLI) and gender and were analyzed separately. Risk factors, prognosticators and longitudinal events (major adverse cardiovascular events, MACE: myocardial infarction, stroke, death) were collected. Data were obtained prospectively from hospital records and death certificates.
RESULTS: 1084 patients (35% women) with symptomatic PAD were included in the study. Mean follow-up period was 45 months, and 371 patients (34%) experienced MACE. Compared to males, females were older (p <0.001) and were more likely to have CLI (p=0.006) and impaired renal func- tion (p <0.001). Diabetes (p=0.043) and smoking (p <0.001) were more prevalent in men, as well as polyvascular disease (p=0.024). No significant difference was found regarding the use of medications. No differences were observed in MACE-free survival between women and men, both in subgroups of patients with intermittent claudication (log-rank p=0.759) and CLI (log-rank p=0.558). CONCLUSIONS: Our study showed no gender differences in the occurrence of MACE based on initial clinical presentations of PAD.
Ključne riječi
peripheral artery disease; critical limb ischemia; gender; cardiovascular outcomes
Hrčak ID:
269881
URI
Datum izdavanja:
27.12.2021.
Posjeta: 468 *