Veterinary Archives, Vol. 91 No. 5, 2021.
Original scientific paper
https://doi.org/10.24099/vet.arhiv.1647
The clinical correlation of findings obtained by fine needle fenestration biopsy of the canine spleen with visible ultrasound changes
Martina Crnogaj
; Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Iva Šmit
; Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Vladimir Mrljak
; Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Sara Došen
; Buba, Veterinary Clinic for Small Animals, Zagreb, Croatia
Marko Hohšteter
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ivana Kiš
; Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Darko Grden
; Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Mirna Brkljačić
; Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Jelena Gotić
; Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Abstract
The medical records databases (March 2016 to March 2021) of the Faculty of Veterinary Medicine, University of Zagreb, were examined to determine the frequency and clinical relevance of cytological diagnoses from fine-needle fenestration biopsy (FNFB) of the spleen in dogs with visible ultrasound changes. Seventy-five dogs were divided into clinically relevant and irrelevant groups, according to the clinical relevance of the diagnosis. The incidence of clinically relevant diagnoses was 28/75 (37.3%). Malignant diagnoses were over-represented (23/28; 82.1%), followed by hemorrhages/hematomas (3/28; 10.7%) and suppurative inflammation (2/28; 7.1%). The most common malignancy was lymphoma (12/28; 42.9%). There was no correlation between the ultrasound lesions examined and the relevant cytological diagnoses, except in cases of patchy echo texture (P = 0.010). Lesion size greater than 1.74 cm had the highest sensitivity/specificity values (91.3%; 42.1%) with a significant area under the curve (AUC) of 0.68 (P = 0.029) for predicting clinically relevant findings. The complication rate due to bleeding was 2/130 (1.5%). In conclusion, splenic FNFB can be safely performed in dogs as it carries a low risk of development of complications. Specific ultrasonographic findings, such as patchy echo texture pattern, may increase the suspicion of the presence of neoplastic disease in the form of lymphoma. According to ROC analysis, lesion size greater than 1.74 increases the possibility of predicting clinically relevant findings.
Keywords
dog; ultrasound; spleen; fine needle fenestration biopsy; cytology
Hrčak ID:
271612
URI
Publication date:
12.12.2021.
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