Izlaganje sa skupa
COMORBIDITIES AND SYNDEMICS IN THE COVID-19 AGE: CHALLENGES AND OPPORTUNITIES FOR BRINGING SEPARATED BRANCHES OF MEDICINE CLOSER TO EACH OTHER
Miro Jakovljevic
orcid.org/0000-0003-0420-357X
; University Hospital Center Zagreb, Zagreb,Croatia
Miroslav Samarzija
; University Hospital Center Zagreb, Zagreb,Croatia
Davor Milicic
; University Hospital Center Zagreb, Zagreb,Croatia
Zeljko Reiner
; University Hospital Center Zagreb, Zagreb,Croatia
Norman Sartorius
; Association for the Improvement of Mental Health Programs, Geneve, Switzerland
Sažetak
The Corona Virus Disease 2019 (COVID-19) as a unique disaster has stressed the extreme importance of the three issues for
medicine, society and humanity in general: comorbidity, pandemic and syndemic. There are many reasons why the study of
comorbidities and syndemics of COVID-19 is of great importance for researchers, clinicians and health policy makers who are
responsible for health care organization and funding in a bid to develop more effective and efficient prevention and treatmen t.
Thinking about COVID-19 through a syndemics concept and taking biological, psychological, social and spiritual dimensions
into account, physicians could be more effective in clinical practice and community-based interventions. The outcome of SARSCoV-
2 infection is determined by the virus-host interaction, with pathogenicity of SARS-CoV-2 being related to the presence of
comorbid diseases. The risk for severe COVID-19 clinical manifestations and death increases with age of patients and comorbidity.
General mechanisms of multi-system dysfunction and multi-organ damage reported in COVID-19 are probably related to
ubiquitous expression of ACE2 in many tissues and its important role in the renin-angiotensin-aldosterone system (RAAS) functioning.
Physicians all over the world should be aware of COVID-19 related comorbidities, multisystem disorders and syndemics, as
well as treatment and preventive strategies. COVID-19 age is a right time to reconsider the state of science and practice in
comorbidity medicine field from the both epistemological and treatment perspective. Comorbidities and multimorbidities are
indifferent to medical specializations, so the integrative and complementary medicine is an imperative in the both education and
practice. Shifting the paradigm from vertical and mono-morbid interventions to comorbidity, multimorbidity and multi-system
disease approaches enhances effectiveness and efficiency of human resources utilization. The aim of this review is to summarize the
theoretical concepts and clinical experience and research regarding comorbidity in general, and specifically related to the COVID-19
pandemic, syndemics and infodemic.
Ključne riječi
comorbidity; multimorbidity; epigenetics; SARS-CoV-2; COVID-19; multi-system disorders; diseases interactions; syndemics
Hrčak ID:
271686
URI
Datum izdavanja:
19.10.2021.
Posjeta: 269 *