Izlaganje sa skupa
INFLUENCE OF SERUM TESTOSTERONE LEVEL ON AGGRESSION IN WOMEN WITH SCHIZOPHRENIA
Adela Klemenčić
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Miroslav Herceg
; University Psychiatric Hospital Vrapče, Zagreb, Croatia; School of Medicine, University of Zagreb, Croatia
Dora Herceg
; School of Medicine, University of Zagreb, Croatia
Krešimir Puljić
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Mirna Sisek-Šprem
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Sažetak
Background: Unlike in female population, the effect of testosterone on aggression in men has been investigated countless times
so far. A scarce number of studies have examined the effect of testosterone on aggression in women. The results obtained so far are
inconsistent for some studies indicated a positive, whilst others showed a negative correlation. Since testosterone turned out to be an
important factor related to aggression in men, the aim of our study was to investigate whether this correlation existed in aggressive
female patients with schizophrenia.
Subjects and methods: The sample consisted of 120 women, aged from 18 to 45 years, diagnosed with schizophrenia by DSM-5
criteria. Those who were breastfeeding or suffered from specific hormonal or other physical disorders were excluded from the study.
They were divided into two groups of 60 - those with aggressive behavior and those with nonaggressive behavior. Psychopathology
was measured by several tests (Positive and Negative Syndrome Scale - PANSS, Overt Aggression Scale - OAS and PANSS Extended
Subscale for Aggression Assessment). Serum testosterone hormone assays were performed. Statistical data analysis was done by
parametric statistical tests, Kolmogorov-Smirnov test, Student's t-test and simple linear regression. All data were presented as mean
values and corresponding standard deviations (SD).
Results: Testosterone levels didn't differ significantly between aggressive and nonaggressive subjects. There were no significant
differences between testosterone levels in suicidal aggressive subjects compared to nonsuicidal aggressive respondents (t=0.616;
p=0.540). The largest number of subjects in both groups had referent testosterone levels.
Conclusions: Despite expecting a significant effect of testosterone levels on aggression in women with schizophrenia, conducted
by previous studies, no correlation has been found testosterone levels.
Ključne riječi
aggression; schizophrenia; testosterone; women
Hrčak ID:
271728
URI
Datum izdavanja:
19.10.2021.
Posjeta: 698 *