Izlaganje sa skupa
DIFFERENCE OF SYMPTOMS NETWORKS IN EARLY AND LATE PHASE SCHIZOPHRENIA; A CROSS-SECTIONAL NETWORK ANALYSIS
Nataša Đuran
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Jelena Sušac
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Domagoj Vidović
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Dina Bošnjak
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Jakša Vukojević
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Žarko Bajić
; Psychiatric Hospital "Sveti Ivan", Zagreb, Croatia
Neven Henigsberg
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Vlado Jukić
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Sažetak
Objective: The functional remission or recovery of schizophrenia patients is a challenging task which relies on pharmacotherapy
but also on the timing of psychotherapy and other therapeutic interventions. The study aimed to assess the difference in strength and
structure of symptoms networks between early and late phase schizophrenia. Our secondary objective was to check whether the
overall, positive, negative, and general symptoms severity change over the course of treatment and disorder.
Methods: This nested cross-sectional analysis combined the samples from two studies performed during 2014-2016 at University
-60 years old diagnosed with schizophrenia, 85 of
ect:
"Biomarkers in schizophrenia - integration of complementary methods in longitudinal follow up of FEP patients".
Results: Median (IQR) age of the participant in the early phase was 36 (32-45) years and in the late phase 44 (38-49) years.
Patients in the early phase had significantly higher odds for being in the symptomatic remission compared to the patients in the latephase
schizophrenia (OR=2.11; 95% CI 1.09-4.09) and had 10% less pronounced negative symptoms. The global strength, density,
and structure of the symptoms network were not significantly different between the two study groups.
Conclusions: Negative symptoms severity change with the course of illness and differ from the early to the late phase of
schizophrenia. However, the overall network of psychotic symptoms is relatively stable, and overall strengths or density and the partial
relationship between particular symptoms do not change significantly. The observed worsening of negative symptoms is probably at
least partially caused by the lack of clear guidelines and effective treatment options aimed specifically toward negative symptoms.
Ključne riječi
schizophrenia; psychosis; PANSS; networks; symptoms
Hrčak ID:
271863
URI
Datum izdavanja:
19.10.2021.
Posjeta: 266 *