Izlaganje sa skupa
ONSET OF SCHIZOPHRENIA PRIOR TO THE END OF BRAIN MATURATION ALTERS GREY MATTER VOLUME LOSS
Antonija Ružić Baršić
orcid.org/0000-0002-3035-3363
; Department of Radiology, Thalassotherapia Opatija, Opatija, Croatia
Lea Gudelj
; Clinic of Psychiatry, Clinical Hospital Centre Rijeka, Rijeka, Croatia ; University of Rijeka, Faculty of Medicine, Rijeka, Croatia
Ronald Antulov
; Department of Radiology and Nuclear Medicine, Hospital South West Jutland, University Hospital of Southern Denmark, Odense, Denmark
Damir Miletić
; Department of Clinical Radiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia; Clinic of Psychiatry, Clinical Hospital Centre Rijeka, Rijeka, Croatia
Koraljka Knežević
; Department of Cardiology, Thalassotherapia Opatija, Opatija, Croatia
Gordana Rubeša
orcid.org/0000-0002-8751-1721
; Clinic of Psychiatry, Clinical Hospital Centre Rijeka, Rijeka, Croatia ; University of Rijeka, Faculty of Medicine, Rijeka, Croatia
Sažetak
Background: Brain maturation is considered completed around the age of 25, when prefrontal cortex maturation has been
achieved. The aim of our study was to investigate the alterations of grey matter (GM) in patients with the onset of schizophrenia
before and after the completion of brain maturation.
Subjects and methods: The study group included 100 schizophrenia patients, while the control group comprised 50 healthy
individuals. Brain magnetic resonance imaging was acquired on a 1.5 T scanner. Voxel-based morphometry (VBM) analyses were
performed between groups.
Results: GM of the schizophrenic patients is reduced in many regions (p<0.005 FDR corrected). Most widespread reduction is
detected in frontal cortex and cerebellum, the other regions being limbic cortex, insula, cuneus, precuneus, superior temporal gyrus
and motor cortex. The decrease of grey matter volume (GMV) increases with the increase in number of psychotic episodes and is
more pronounced in the patients with earlier onset of the disease.
Conclusions: The age of the onset of the disease is important for both total and relative loss of GMV. Earlier onset of
schizophrenia, prior to full brain maturation results in significant reduction of GM in comparison with healthy subjects and patients
with later, post full brain maturation onset of the disease.
Ključne riječi
schizophrenia; brain maturation; voxel-based morphometry
Hrčak ID:
271864
URI
Datum izdavanja:
19.10.2021.
Posjeta: 228 *