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Psychiatria Danubina, Vol. 33 No. suppl 13, 2021.

Review article

COGNITIVE ASPECTS IN MULTIPLE SCLEROSIS

Marijana Lisak orcid id orcid.org/0000-0002-1225-6922 ; Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia ; School of Dental Medicine, University of Zagreb, Croatia
Bruno Špiljak orcid id orcid.org/0000-0003-2545-4474 ; School of Dental Medicine, University of Zagreb, Croatia
Hanna Pašić ; Department of Psychiatry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Zlatko Trkanjec ; Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia ; School of Dental Medicine, University of Zagreb, Croatia

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Abstract

Background: Cognitive dysfunction appears all through the course of multiple sclerosis (MS). Mild and moderate cognitive
impairment is present in up to 40% of MS patients and severe cognitive decline affects more than 50% of patients in progressive
course of the disease. The most common cognitive disorders in MS include diminished information processing speed, compromised
word fluency, complex attention deficit and executive dysfunction.
Methods: In this mini review, we present the reader with the most common neuropsychological assessments for the evaluation of
cognition in MS, addressing the question of cognitive relapse. Source of data presented in this review is PubMed search of the
recently published literature on cognitive decline in MS.
Results: Patients with cognitive relapse often fail to meet diagnostic criteria for classical relapse in MS. Although, cognitive
decline relates poorly to functional disability in MS, it correlates well with neuropsychological testing and with neuroimaging
parameters of the disease.
Conclusions: Cognitive decline might be considered as additional indicator of MS activity, and therefore evaluated routinely,
irrespective of clinical presentation. Brief cognitive assessment, with confirmed psychometric qualities, might be useful in detection
of cognitive relapse in MS patient.

Keywords

multiple sclerosis; cognitive decline; cognitive relapse

Hrčak ID:

272663

URI

https://hrcak.srce.hr/272663

Publication date:

8.2.2022.

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