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PREDICTORS OF QUALITY OF LIFE IN PATIENTS WITH DRUG RESISTANT EPILEPSY AFTER NEUROSURGICAL TREATMENT: ONE-YEAR FOLLOW-UP
Dragana Mijatović
orcid.org/0000-0002-1082-1238
; Istrian Health Center, Umag Section, Umag, Croatia ; School of Medicine, University of Rijeka, Rijeka, Croatia
Željka Petelin Gadže
; Department of Neurology, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia
Elizabeta Dadić-Hero
orcid.org/0000-0002-3119-5205
; Department od Social Medicine and Epidemiology, School of Medicine, University of Rijeka, Primorje-Gorski Kotar County Health Center, Rijeka, Croatia
Andrica Lekić
orcid.org/0000-0002-6175-635X
; Department of Basic Medical Sciences, Faculty of Health Studies, University of Rijeka, Rijeka, Croatia
Sanja Hajnšek
; School of Medicine, University of Zagreb, Zagreb, Croatia - retired
Sažetak
Background: Invasive neurosurgical treatment or minimally invasive neurosurgical treatment are methods of choice for the
treatment of patients with drug resistant epilepsy. The aim of this study was to evaluate the impact of neurosurgical treatment and
the quality of life of patients with drug resistant epilepsy and to determine what are the potential predictors of quality of life of
patients with drug resistant epilepsy one year after neurosurgical treatment.
Subjects and methods: The research was performed at the Referral Centre for Epilepsy, Department of Neurology, University
Hospital Centre Zagreb from February 2015 to February 2020 with Ethics commitee approval. The study included 96 patients with
drug resistant epilepsy who were examined for the quality of life before and one year after neurosurgical treatment using the form
questionnaire "Quality of life in epilepsy" (QOILE-31) validated Croatian 1.0 version and the questionnaire to assess the degree of
depression "Beck Depression Inventory I" (BDI-I) validated Croatian version.
Results: Of 96 patients with drug resistant epilepsy one year after neurosurgical treatment 46 (47.9%) patients remained
completely free from epileptis seizures. Wilcoxon equivalent pair test showed that the number of epileptic seizures one year after
neurosurgical treatment was significantly lower (median before neurosurgical treatment is 10; and after neurosurgical treatment is 1,
p<0.001). The most informative potential statistically significant predictor variables of quality of life based on the criterion variables
QOLIE-31 and BDI-I are: total disease duration in years (p=0.034), patient age (p=0.042), number of antiepileptics one year after
neurosurgical treatment (p=0.001), the number of epileptic seizures per month (p=0,016), and social welfare rights (p=0.045).
Conclusion: Neurosurgical treatment of patients with drug resistant epilepsy significantly reduces the number of epileptic
seizures which significantly improves their overall quality of life one year after neurosurgical treatment.
Ključne riječi
drug resistant epilepsy; neurosurgical treatment
Hrčak ID:
272954
URI
Datum izdavanja:
8.2.2022.
Posjeta: 323 *