Skip to the main content

Journal of Electrochemical Science and Engineering, Vol. 12 No. 2, 2022.

Original scientific paper

https://doi.org/10.5599/jese.1162

Synthesis and antioxidant activity of six novel N-ferrocenyl-methyl-N-(nitrophenyl)- and -N-(cyanophenyl)-acetamides: Cyclic voltammetry and molecular docking studies

Abdellatif Kedadra orcid id orcid.org/0000-0001-9549-0038 ; VTRS Laboratory, Department of Chemistry, Faculty of Sciences, University of El Oued, El Oued, Algeria
Touhami Lanez orcid id orcid.org/0000-0002-3978-7635 ; VTRS Laboratory, Department of Chemistry, Faculty of Sciences, University of El Oued, El Oued, Algeria
Elhafnaoui Lanez ; VTRS Laboratory, Department of Chemistry, Faculty of Sciences, University of El Oued, El Oued, Algeria
Hadia Hemmami ; VTRS Laboratory, Department of Chemistry, Faculty of Sciences, University of El Oued, El Oued, Algeria
Meriem Henni ; VTRS Laboratory, Department of Chemistry, Faculty of Sciences, University of El Oued, El Oued, Algeria

Full text: english pdf 1.563 Kb

page 293-304

downloads: 174

cite

Abstract

Cyclic voltammetry (CV) assays were performed to measure superoxide anion radical (O2-) scavenging activities of six novel N-ferrocenylmethyl-N-(nitrophenyl)-acetamides and N-fer­rocenylmethyl-N-(cyanophenyl)acetamides (FMA1-FMA6), followed by molecular docking simulations and in silico toxicity prediction. The obtained values of IC50 from CV assays indicated that all studied compounds showed promising scavenging activity against O2- radicals, with the compounds FMA1, FMA3, and FMA4 possessing the most significant potency. A molecular docking study revealed that all compounds interact with amino acid residues of glutathione reductase via hydrogen bonding and hydrophobic interactions. The compound FMA4 was the most inactive compound against the glutathione reductase enzyme having the highest inhibitory concentration of 2.61 µM and the lowest docking score of -31.85 kJ/mol. Toxicity studies demonstrated that among six studied compounds, FMA4, FMA5, and FMA6 are predicted to be nontoxic.

Keywords

Ferrocene derivatives, superoxide anion radical, binding free energy, toxicity study

Hrčak ID:

273957

URI

https://hrcak.srce.hr/273957

Publication date:

7.3.2022.

Visits: 504 *