Veterinarski arhiv, Vol. 75 No. 6, 2005.
Izvorni znanstveni članak
Pharmacokinetics of enrofl oxacin in inbred and outbred rabbits
Svetlin Tanchev
; Department of Genetics, Breeding and Reproduction, Agricultural Faculty, Trakia University, Bulgaria
Ljubomur Lashev
; Department of Pharmacology, Toxicology and Therapeutics, Faculty of Veterinary Medicine, Trakia University, Bulgaria
Aneliya Haritova
; Department of Pharmacology, Toxicology and Therapeutics, Faculty of Veterinary Medicine, Trakia University, Bulgaria
Sažetak
The pharmacokinetics of enrofloxacin (ENR) were investigated after intravenous (i/v) administration in inbred (n = 10) and outbred (n = 10) healthy rabbits. After i/v ENR injection the elimination half-life (t1/2β), total body clearance (ClB) and the area under the concentration vs. time curve (AUC) in inbred rabbits were 1.51 h, 28.35 ± 1.51 ml/kg/min and 3.01 ± 0.16 μg.h/ml, respectively. The value of t1/2β in outbred rabbits was 2.12 h. The value of ClB (21.47 ± 1.16 ml/kg/min) was significantly lower in outbred rabbits. There were no differences in pharmacokinetic parameters between male outbred and inbred rabbits, and only the value of ClB in female outbred rabbits was significantly lower in comparison to inbred animals. The phenotypic diversity, a manifestation of the complex interaction among the genotype and the environmental factors (the ENR treatment), was clearly less manifested in the inbred group than in outbreds.
Ključne riječi
enrofloxacin; pharmacokinetics; inbred; outbred; rabbits
Hrčak ID:
25200
URI
Datum izdavanja:
20.12.2005.
Posjeta: 1.435 *