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Croatian Medical Journal, Vol. 61 No. 4, 2020.

Original scientific paper

Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study

Milena Gašparović Krpina ; Department of Gynecology and Obstetrics, Clinical Hospital Centre Rijeka, Rijeka, Croatia
Anita Barišić ; Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Ana Peterlin ; Clinical Institute for Genomic Medicine, UMC Ljubljana, Ljubljana, Slovenia
Nataša Tul ; Division of Obstetrics and Gynecology, Department of Perinatology, UMC Ljubljana, Ljubljana, Slovenia
Saša Ostojić ; Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Nina Pereza ; Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Borut Peterlin ; Clinical Institute for Genomic Medicine, UMC Ljubljana, Ljubljana, Slovenia

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Abstract

Aim To evaluate the association between the FokI
(rs2228570), ApaI (rs7975232), Bsml (rs1544410), TaqI (rs
731236), and Cdx2 (rs11568820) single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene
and spontaneous preterm birth (SPTB), as well as their effect on clinical characteristics of women with SPTB and
their newborns.
Methods This case-control study enrolled women who
gave birth at the Department of Obstetrics and Gynecology, University Medical Center Ljubljana between 2010 to
2019. Cases were 118 women with spontaneous initiation
of PTB after natural conception and 119 controls with a
term singleton delivery after an uncomplicated pregnancy.
The molecular analysis of VDR SNPs employed polymerase
chain reaction and restriction fragment length polymorphism.
Results Patients and controls did not significantly differ
in the distribution of genotype or allele SNP frequencies.
However, the FokI polymorphism had a significant effect
on newborn birth weight in women with SPTB but not in
controls (F=5.17, P=0.007, one-way ANOVA with post-hoc
Scheffe test), with newborns of FokI TT carriers having the
lowest birth weight (P=0.011). No other VDR SNP was associated with any other clinical characteristic of women
with SPTB and their newborns.
Conclusion The TT genotype of the VDR FokI polymorphism is associated with newborn birth weight in women
of European origin with SPTB

Keywords

Hrčak ID:

274619

URI

https://hrcak.srce.hr/274619

Publication date:

31.8.2020.

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