Veterinarski arhiv, Vol. 75 No. 6, 2005.
Izvorni znanstveni članak
The effects of oral manganese chloride supplementation on the severity of Trypanosoma brucei and Trypanosoma congolense infections in rats
Tobias Nnia Egbe-Nwiyi
; Department of Veterinary Pathology, University of Maiduguri, Maiduguri, Nigeria
Anastasia Nwaosu
; Department of Veterinary Pathology, University of Maiduguri, Maiduguri, Nigeria
Medugu Apagu Gazdama
; Department of Veterinary Pathology, University of Maiduguri, Maiduguri, Nigeria
Sažetak
Eighty healthy adult albino rats of both sexes were used in two experiments to study the effects of manganese chloride supplementation on the severity of Trypanosoma brucei and Trypanosoma congolense infections. In each experiment, forty rats were divided into four groups of 10 each: A. Infected unsupplemented; B. Infected supplemented; C. Uninfected unsupplemented control; D. Uninfected supplemented control. Aqueous solution
(5%) of MnCl2 was administered daily using stomach tube to each rat at 50 mg/kg body weight in groups B and D from 10 days before infection to the end of the experiment. Each rat in groups A and B was infected by intraperitoneal injection of 1x106 trypanosomes (T. brucei or T. congolense) in diluted donor blood. The prepatent periods were shorter (P<0.05) in T. brucei than T. congolense infections, and shorter (P<0.05) in infected unsupplemented than in infected supplemented rats. The infected unsupplemented groups had higher (P < 0.05) parasitaemia and more severe anaemia than the infected supplemented groups. Therefore, oral manganese chloride supplementation in rats appeared to reduce the severity of trypanosome infections by delaying the onset of parasitaemia, reducing the levels of parasitaemia and accompanying anaemia.
Ključne riječi
manganese chloride; Trypanosoma brucei; Trypanosoma congolense; rats
Hrčak ID:
25271
URI
Datum izdavanja:
20.12.2005.
Posjeta: 991 *