Skoči na glavni sadržaj

Izvorni znanstveni članak

https://doi.org/10.20471/acc.2021.60.04.03

Depression, Anxiety and Quality of Life in Patients with Chronic Hepatitis C Virus Infection in Vojvodina

Dragana Kačavenda-Babović
Predrag Đurić
Radomir Babović
Milotka Fabri
Maja Ružić
Vojislava Bugarski Ignjatović


Puni tekst: engleski pdf 274 Kb

str. 579-589

preuzimanja: 211

citiraj


Sažetak

The objective of this study was to investigate the prevalence of depression and
anxiety among patients with chronic hepatitis C and how depression and anxiety correlate with respective
health-related quality of life (HRQoL) domains, sociodemographic factors, and clinico-epidemiological
characteristics. This prospective study involved 150 patients with chronic hepatitis C
awaiting interferon treatment for hepatitis C and 150 healthy subjects. All individuals enrolled in the
study completed the Short Form 36 (SF-36) questionnaire and Hospital Anxiety Depression Scale.
The symptoms showed greater severity/score among patients with chronic hepatitis C for both depression
(t=3.37; p<0.01) and anxiety (t=2.35; p<0.05). Regression analysis was used for estimating the
relationship between depression and the set of predictors (domains of the SF-36 questionnaire). Three
HRQoL domains (Physical Functioning, Vitality, and Mental Health) were found to have the strongest
predictive contribution to the occurrence of depression. A series of Kruskal-Wallis and Mann-
Whitney tests showed a significant difference in depression level between marital status categories
(χ2(2)=7.86, p<0.05). Divorced participants had significantly higher scores compared to married participants
(Z=-2.40, p<0.05) and single participants (Z=-2.75, p<0.01). Unemployment was associated
with a higher degree of depression and anxiety. There was no association identified between duration
of the disease, route of hepatitis C virus transmission, existence of cirrhosis, and depression or anxiety.
The findings of this study can assist in developing a standard protocol for the management of chronic
hepatitis C that will include psychological assessment and support.

Ključne riječi

Chronic hepatitis C; Quality of life; Depression; Anxiety; Socioeconomic factors

Hrčak ID:

275429

URI

https://hrcak.srce.hr/275429

Datum izdavanja:

1.12.2021.

Podaci na drugim jezicima: hrvatski

Posjeta: 730 *