Izvorni znanstveni članak
HER-2 protein expression and its prognostic value in breast cancer – overview of experience at the University Hospital for Tumors, Zagreb, Croatia
Robert Zorica
; Department of Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Božena Šarčević
; Department of Clinical Pathology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Miroslav Banović
; Department of Transfusion Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mario Puljiz
; Department of Gynecologic Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Jerolima Pinjatela
; Department of Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sažetak
Immunohistochemical analysis of the HER-2 protein expression in ductal invasive breast cancer was done on archival paraffin-embedded breast cancer tissue using specific monoclonal antibodies. All of the 190 analyzed patients were treated at the University Hospital for Tumors, Zagreb, Croatia, from September 2002 to September 2003. Year of birth, tumor size, histological type of tumor, histological grade, lymph-node status, steroid receptors, HER-2 expression, nuclear grade and vascular invasion were determined for each patient. HER-2 overexpression was found in 24% of the patients. HER-2 overexpression was not associated with age, but it was associated significantly with tumor size, worse histological and nuclear grades, lack of steroid receptors, lymph node involvement and positive vascular invasion. Steroid receptors expression was associated significantly with better nuclear grade and negative vascular invasion.
Ključne riječi
breast cancer; HER-2; immunohistochemical analysis
Hrčak ID:
276098
URI
Datum izdavanja:
30.11.2011.
Posjeta: 402 *